NIH awards $15M for 3D human tissue models

The National Institutes of Health has announced 13 two-year awards, totaling $15 million a year, for hospitals and universities to develop 3D human tissue models. The funding will go toward the first phase of a five-year program. Even though pre-clinical studies using cell and animal research models are promising, more than 60% of investigational drugs

3D-printed organ developer BioLife4D seeks $50 million IPO

Biological 3D printing developer BioLife4D has filed for a $50 million initial public offering as it looks to commercialize its cardiac tissue regeneration and organ replacement processes. The Chicago-based company said yesterday it is developing technologies with an end goal of creating a 3D bioprinted viable human heart suitable for transplant. Funds from the offering

Is this the key to rapidly manufacturing heart valves?

Nanofiber fabrication may be the key to rapidly manufacturing heart valves with regenerative and growth potential, according to new research from Harvard University’s Wyss Institute for Biologically Inspired Engineering. A research team led by Kevin Kit Parker created a valve-shaped nanofiber network that replicates the mechanical and chemical properties of the native valve extracellular matrix (ECM).

This exoskeleton could eliminate crouch gait

The National Institutes of Health has created what it claims is the first robotic exoskeleton that is designed to treat crouch gait in children who have cerebral palsy. Crouch gait occurs when there is excessive bending of the knees while walking. It is a common condition in children with cerebral palsy. The NIH reports that

Cell stacking technology creates living human organs

Research engineers at Brown University have figured out a way to build tiny versions of human organs one micro-level at a time, and Igus technology helped enable the innovation. Using cells that are shaped as microscopic honeycomb-like patterns, Jeffrey Morgan, a professor at the university, created a method that consists of precisely stacking molded cells and

This tissue paper is made from actual organ tissues

Northwestern University researchers have created biomaterials made from animal organs and tissues that could potentially support natural hormone production in young cancer patients and aid wound healing. The materials, aptly named tissue papers, are made from structural proteins that are excreted by cells and give organs their forms and structures. The tissue papers are thin and

Magnetic fields can destroy biofilms on implants: Here’s how

Alternating magnetic fields may be the key to fighting bacteria that grows on artificial joints, according to new research from the University of Texas Southwestern. Researchers at UT Southwestern claim that short exposure to high-frequency alternating magnetic fields (AMF) has the potential to destroy bacteria that ends up in biofilms growing on the surface of

Lab-engineered tissue is creating new digestive tract treatments

Wake Forest Baptist Medical Center have reported success with lab-engineered tissue replacements to treat digestive system diseases. The research team demonstrated the effectiveness of growing anal sphincters in a lab to treat an animal model for fecal incontinence. The success comes after the researchers reported success in implanting human-engineered intestines in rodents. “Results from both

This new nanochip technology can reprogram human cells

Ohio State University researchers have developed a nanochip technology that they say can create any cell type for treatment within the human body. The new technology, called Tissue Nanotransfection (TNT), can repair injured tissue and restore the function of aging tissue like organs, blood vessels and nerve cells. “By using our novel nanochip technology, injured

First patient treated with Biostage’s esophageal implant

Biostage (NSDQ:BSTG) touted today the first patient use of its Cellspan esophageal implant. The Holliston, Mass.-based company said that the regenerative implant was used in a 75-year old male patient, who has a life-threatening cancerous mass in his chest. Surgeons removed the portion of his esophagus affected by the cancer and Biostage’s implant was used to

New non-invasive brain stimulation method could treat autism and more

Massachusetts Institute of Technology researchers have figured out how to non-invasively deliver electrical stimulation to specific parts of the brain. In collaboration with Beth Israel Deaconess Medical Center (BIDMC) and the IT’IS Foundation, the MIT researchers have placed electrodes on the scalps of patients to stimulate regions that are deep in the brain, making a

Could dogs be better than medical devices at detecting cancer?

Dogs in a small Japanese town are being trained to detect stomach cancer through their scent to try to combat the high rates of stomach cancer in the area, according to media reports. The small 6,000-resident Japanese town of Kaneyama has high rates of stomach cancer and Mayor Hiroshi Suzuki has taken to a sniffer

Stem cells and graphene can regenerate nerves: Here’s how

Iowa State University researchers have developed a nanotechnology that turns mesenchymal stem cells into Schwann cells for nerve regeneration. Schwann cells form sheaths around axons on nerves and promote regeneration of axons. They also produce substances that help promote the health of nerve cells. Both actions are helpful for researchers who are looking to regenerate

Infertility: There could be a 3D printing solution

New Northwestern University research offers a potential 3D printing solution for women’s infertility – providing hope for cancer survivors who want to start families. The Northwestern researchers successfully 3D printed a bioprosthetic mouse ovary that ovulated when implanted inside a live mouse. Mice with the bioprosthetic ovaries were able to give birth to live pups,

Engineered tissue could eliminate radiation for bone marrow transplants

University of California San Diego engineers have created artificial bone tissue that could eliminate the need for radiation before bone marrow transplants. Shyni Varghese, a bioengineering professor at UC San Diego Jacobs School of Engineering, led a team to develop a bone-like implant to eliminate the pre-treatment radiation that kills stem cells in a patient’s bone