Medical Design and Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Supplies and Components Index
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • MedTech Resources
    • Medtech Events in 2025
    • The 2024 Medtech Big 100
    • Medical Device Handbook
    • MedTech 100 Index
    • Subscribe to Print Magazine
    • DeviceTalks
    • Digital Editions
    • eBooks
    • Educational Assets
    • Manufacturer Search
    • Podcasts
    • Print Subscription
    • Webinars / Digital Events
    • Whitepapers
    • Voices
    • Video
  • 2025 Leadership
    • 2024 Winners
    • 2023 Winners
    • 2022 Winners
    • 2021 Winners
  • Women in Medtech
  • Advertise
  • Subscribe

3D Scaffolds a New Tool to Fight Cancer

April 2, 2013 By Rice University

Porous polymer scaffolds fabricated to support the growth of biological tissue for implantation may hold the potential to greatly accelerate the development of cancer therapeutics.

Researchers at Rice University and the University of Texas MD Anderson Cancer Center in Houston and Mount Sinai Medical Center in New York reported this week that three-dimensional scaffolds used to culture Ewing’s sarcoma cells were effective at mimicking the environment in which such tumors develop.

Their research appears online this week in the Proceedings of the National Academy of Sciences.

“The scaffolds better recapitulate the microenvironment in which tumors grow, as compared with two-dimensional plastic surfaces typically used in cancer research to test anti-cancer drugs,” said Rice bioengineer Antonios Mikos, who led the research team with Joseph Ludwig, an assistant professor and sarcoma medical oncologist at MD Anderson.

“We’ve been working to investigate how we can leverage our expertise in engineering normal tissues to cancerous tissues, which can potentially serve as a better predictor of anti-cancer drug response than standard drug-testing platforms,” Mikos said.

By growing cancer cells within a three-dimensional scaffold rather than on flat surfaces, the team of researchers found that the cells bore closer morphological and biochemical resemblance to tumors in the body. Additionally, engineering tumors that mimic those in vivo offers opportunities to more accurately evaluate such strategies as chemotherapy or radiation therapies, he said.

The project “provides a path forward to better evaluate promising biologically targeted therapies in the preclinical setting,” Ludwig said.

Scaffolds fabricated in the Mikos’ lab facilitate the development and growth of new tissue outside the body for subsequent implantation to replace defective tissues.

The team found 3D scaffolds to be a suitable environment for growing Ewing’s sarcoma, the second most-common pediatric bone malignancy. The tumor growth profile and protein expression characteristics were “remarkably unlike” those in 2D, Mikos said.

These differences led them to hypothesize that 2D cultures may mask the mechanisms by which tumors develop resistance to anti-cancer therapeutics, and “may lead to erroneous scientific conclusions that complicate our understanding of cancer biology,” they wrote.

The next challenge is to customize scaffolds to more accurately match the actual conditions in which these tumors are found. “Tumors in vivo exist within a complex microenvironment consisting of several other cell types and extracellular matrix components,” Mikos said. “By taking the bottom-up approach and incorporating more components to this current model, we can add layers of complexities to make it increasingly reliable.

“But we believe what we currently have is very promising,” he said. “If we can build upon these results, we can potentially develop an excellent predictor of drug efficacy in patients.”

Co-authors are, from Rice, graduate students Eliza Fong and Emily Burdett; Kurt Kasper, a faculty fellow in bioengineering; and Mary Farach-Carson, Ralph and Dorothy Looney Professor of Biochemistry and Cell Biology and vice provost for translational bioscience; from MD Anderson, senior research scientist Salah-Eddine Lamhamedi-Cherradi, research assistants Vandhana Ramamoorthy and Brian Menegaz, Department of Pathology Associate Professor Alexander Lazar, graduate student Deeksha Vishwamitra and Department of Hematopathology Associate Professor Hesham Amin; and, from Mount Sinai Center, Assistant Professor Elizabeth Demicco. Mikos is the Louis Calder Professor of Bioengineering and Chemical and Biomolecular Engineering at Rice.

The National Institutes of Health, a National University of Singapore-Overseas Graduate Scholarship and an MD Anderson Support Grant supported the research.

For more information visit www.rice.edu.

Related Articles Read More >

Verily Study Watch
Verily says its Study Watch could identify heart failure risk
A child using a medical device at home.
Device design takes the spotlight among 2024’s top health tech hazards
These 11 medical device inventions are the best of 2023, Time magazine says
A photo of a Best Buy Geek Squad employee helping a chronic care patient with a remote monitoring device.
Device manufacturers have an unexpected ally for at-home health care
“mdo
EXPAND YOUR KNOWLEDGE AND STAY CONNECTED
Get the latest medical device business news, application and technology trends.

DeviceTalks Weekly

See More >

MDO Digital Edition

Digital Edition

Subscribe to Medical Design & Outsourcing. Bookmark, share and interact with the leading medical design engineering magazine today.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
DeviceTalks

DeviceTalks is a conversation among medical technology leaders. It's events, podcasts, webinars and one-on-one exchanges of ideas & insights.

DeviceTalks

New MedTech Resource

Medical Tubing

MassDevice

Mass Device

The Medical Device Business Journal. MassDevice is the leading medical device news business journal telling the stories of the devices that save lives.

Visit Website
MDO ad
Medical Design and Outsourcing
  • MassDevice
  • DeviceTalks
  • MedTech100 Index
  • Medical Tubing + Extrusion
  • Medical Design Sourcing
  • Drug Delivery Business News
  • Drug Discovery & Development
  • Pharmaceutical Processing World
  • R&D World
  • About Us/Contact
  • Advertise With Us
  • Subscribe to Print Magazine
  • Subscribe to our E-Newsletter
  • Listen to our Weekly Podcasts
  • Join our DeviceTalks Tuesdays Discussion

Copyright © 2025 WTWH Media, LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media LLC. Site Map | Privacy Policy | RSS

Search Medical Design & Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Supplies and Components Index
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • MedTech Resources
    • Medtech Events in 2025
    • The 2024 Medtech Big 100
    • Medical Device Handbook
    • MedTech 100 Index
    • Subscribe to Print Magazine
    • DeviceTalks
    • Digital Editions
    • eBooks
    • Educational Assets
    • Manufacturer Search
    • Podcasts
    • Print Subscription
    • Webinars / Digital Events
    • Whitepapers
    • Voices
    • Video
  • 2025 Leadership
    • 2024 Winners
    • 2023 Winners
    • 2022 Winners
    • 2021 Winners
  • Women in Medtech
  • Advertise
  • Subscribe