Medical Design and Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Contract Manufacturing
  • Med Tech Resources
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • Suppliers
    • The Big 100
      • Archive – The Big 100 (2018)
    • Webinars
    • Whitepapers
    • Video
  • Leadership
    • Women in Medtech
    • 2020 Winners
    • 2019 Winners

Artificial spider silk: Why you should care about it

January 10, 2017 By Danielle Kirsh

artificial spider silk

[Photo courtesy unsplash.com]

A spider expert and a chemist walk into a lab at the University of Nottingham. No, this isn’t how the next Spider-Man movie begins. It is, however, how a group of scientists developed an antibiotic synthetic spider silk that can be used in a variety of medical applications.

Neil Thomas, professor of medicinal and biological chemistry, and Sara Goodacre, lead researcher in the “SpiderLab” at Nottingham and associate professor of medicine and health sciences, led a team of PhD students to use click chemistry to attach antibiotics to artificially produced spider silk that has been synthesized by E.coli to be used in drug delivery, regenerative medicine and wound healing.

Silk proteins had to be created in a bacterium where amino acids in proteins were not normally found. The amino acid had an azide group that is used in click chemistry reactions that only happen at that position in the protein.

Chosen molecules, like antibiotics or fluorescent dyes, can be attached to soluble silk protein. The research team discovered that when the silk fibers are coated in the antibiotic levofloxacin, the antibacterial properties are held on to for at least five days.

“Our technique allows the rapid generation of biocompatible, mono or multi-functionalized silk structures for use in a wide range of applications. These will be particularly useful in the fields of tissue engineering and biomedicine,” said Thomas.

Spider silk has strong, biocompatible and biodegradable properties and is a protein-based material that does not have any allergens or cause immune or inflammatory reactions. The research team developed a way to have the artificial spider silk have the same properties while being a replacement for the cellular matrix that human cells create and accelerate the growth of new cells while slowly releasing antibiotics.

“There is the possibility of using the silk in advanced dressings for the treatment of slow-healing wounds such as diabetic ulcers. Using our technique, infection could be prevented over weeks or months by the controlled release of antibiotics. At the same time tissue regeneration is accelerated by silk fibers functioning as a temporary scaffold before being biodegraded,” said Thomas.

Spider silk is the strongest known natural fiber and has been used in medical applications for centuries. It was known to ease healing and connect the skin. It was also believed that spider silk had antiseptic properties and was effective in clotting blood because of its high vitamin K content. Greek and Roman soldiers used to ball up spider webs and put them in open wounds to stop bleeding.

Thomas and Goodacre met at a University of Nottingham meeting five years ago when Goodacre showed the audience a picture of spider silk and told them that she wanted to figure out how it works and recreate it. Thomas approached her and said that he thought his research team could create the synthetic spider silk with added, useful compounds.

The research was funded by Biotechnology and Biological Science Research Council and was published in the online Advanced Materials journal.

Comments

  1. Rebeccah Mildenstein says

    January 14, 2017 at 7:27 pm

    Wow this is incredible! I love medical science!

Related Articles Read More >

SeaSpine gains FDA clearance for new uses of surface technology
Spectrum Plastics acquires PeelMaster Medical
Swiss scientists make ‘micromachines’ for self-deploying stents and more
Biomodex garners ISO 13485 certification

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.

MDO Digital Edition

Digital Edition

Subscribe to Medical Design & Outsourcing. Bookmark, share and interact with the leading medical design engineering magazine today.

DeviceTalks

DeviceTalks is a conversation among medical technology leaders. It's events, podcasts, webinars and one-on-one exchanges of ideas & insights.

DeviceTalks

New MedTech Resource

Medical Tubing

Enewsletter Subscriptions

Tweets by MedTechDaily

MassDevice

Mass Device

The Medical Device Business Journal. MassDevice is the leading medical device news business journal telling the stories of the devices that save lives.

Visit Website
MDO ad
Medical Design and Outsourcing
  • MassDevice
  • DeviceTalks
  • Drug Delivery Business News
  • Medical Tubing + Extrusion
  • About Us/Contact
  • Advertising
  • Subscribe to Enewsletter
  • Subscribe to Print Magazine

Copyright © 2021 WTWH Media, LLC. All Rights Reserved. Site Map | Privacy Policy | RSS

Search Medical Design & Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Contract Manufacturing
  • Med Tech Resources
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • Suppliers
    • The Big 100
      • Archive – The Big 100 (2018)
    • Webinars
    • Whitepapers
    • Video
  • Leadership
    • Women in Medtech
    • 2020 Winners
    • 2019 Winners