Medical Design and Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech

Biodegradable Polymers Made by Chemical Vapor Deposition

December 7, 2016 By Phys.org

Polymerization by chemical vapor deposition (CVD) is a simple method for modifying surfaces by which topologically challenging substrates can be evenly coated with polymers. In the journal Angewandte Chemie, researchers have now introduced the first CVD method for producing degradable polymers. Biomolecules or drugs can be attached by means of special side groups. This introduces new possibilities for applications like the coating of biodegradable implants.

In CVD polymerization, the starting compounds are vaporized, activated at high temperature, and deposited onto surfaces, where they polymerize. In medical applications, substrates for implants are coated to allow functional groups to be added as anchors for the attachment of biomolecules or drugs. Until now, however, it has only been possible to coat nondegradable implants, not materials that need to degrade after fulfilling their task, like surgical sutures, systems for controlled drug delivery, drug-eluding stents, or tissue engineering scaffolds. This is because it was previously not possible to make degradable coatings by CVD.

(Credit: Wiley)

Scientists from the University of Michigan (Ann Arbor, USA), Northwestern Polytechnical University (Xi’an, China), and the Karlsruhe Institute of Technology (KIT, Eggenstein-Leopoldshafen, Germany) have now synthesized the first CVD polymer with a degradable backbone. The research team led by Jörg Lahann succeeded by using two special types of monomer: The paracyclophanes usually used for this process were combined with cyclic ketene acetals. While the classic polymers based on paracyclophanes are connected exclusively through carbon-carbon bonds, the ketene acetal converts during the polymerization so that ester bonds (a bond between a carbon and an oxygen atom) are formed within the polymer backbone. Ester bonds can be broken in aqueous environments.

“The speed of the degradation depends on the ratio of the two types of monomer as well as their side chains,” explains Lahann. “Polar side chains make the polymer film less hydrophobic and accelerate degradation because water can penetrate more easily. The speed of degradation can thus be tailored to the intended use.” Tests with cell cultures demonstrated that neither the polymer nor its degradation products are toxic.

The team produced polymer films that were equipped with functional side groups that act as “anchor points” for molecules, which can be used to attach fluorescence dyes and biomolecules. “Our new degradable polymer films could find broad application for the functionalization and coating of surfaces in the biological sciences as well as medicine and for food packaging applications,” states Lahann.

Related Articles Read More >

Johnson & Johnson Office of Digital Innovation Leader Peter Schulam
Imagining the future of cloud-connected medical devices with Johnson & Johnson leaders
Withings Body Scan
Withings plans launch for Body Scan smart scale platform
BinaxNow COVID-19 Ag Card
Time recognizes Abbott offerings among this year’s 100 best inventions
Koya Medical’s Dayspring device
Koya Medical reports positive early results in Dayspring lymphedema trial

DeviceTalks Weekly.

May 27, 2022
Quick message - No DTW podcast, but plenty else to listen to over this weekend and next week.
See More >

MDO Digital Edition

Digital Edition

Subscribe to Medical Design & Outsourcing. Bookmark, share and interact with the leading medical design engineering magazine today.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
DeviceTalks

DeviceTalks is a conversation among medical technology leaders. It's events, podcasts, webinars and one-on-one exchanges of ideas & insights.

DeviceTalks

New MedTech Resource

Medical Tubing

Enewsletter Subscriptions

Enewsletter Subscriptions

MassDevice

Mass Device

The Medical Device Business Journal. MassDevice is the leading medical device news business journal telling the stories of the devices that save lives.

Visit Website
MDO ad
Medical Design and Outsourcing
  • MassDevice
  • DeviceTalks
  • MedTech 100 Index
  • Medical Tubing + Extrusion
  • Drug Delivery Business News
  • Drug Discovery & Development
  • Pharmaceutical Processing World
  • R&D World
  • About Us/Contact
  • Advertise With Us
  • Subscribe to Print Magazine
  • Subscribe to E-newsletter
  • Attend our Monthly Webinars
  • Listen to our Weekly Podcasts
  • Join our DeviceTalks Tuesdays Discussion

Copyright © 2022 WTWH Media, LLC. All Rights Reserved. Site Map | Privacy Policy | RSS

Search Medical Design & Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech