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CorMatrix Cardiovascular Receives U.S. Patent for Injectable Biomaterial

January 16, 2014 By Business Wire

CorMatrix Cardiovascular, Inc., a leading medical device developer, today announced the issuance of U.S. Patent No. 8,568,761 for an augmented injectable extracellular matrix (ECM) bioscaffold. The augmented ECM bioscaffold induces stem cell proliferation and differentiation of stem cells into cardiomyocytes, and, thereby, angiogenesis and remodeling, i.e. tissue repair, of cardiovascular tissue.

U.S. Patent No. 8,568,761 is based on one of multiple pending U.S. Applications with claims directed toward ECM bioscaffolds that are augmented with a variety of bioactive components, such as TGF-2, TGF-β and DNA.

“Capturing and directing stem cell function for truly regenerating tissues requires the appropriate microenvironment, not just stem cells,” said Robert Matheny, M.D., a cardiovascular surgeon and chief scientific officer for CorMatrix. “The future of regenerative therapy will be directed toward enhancing our effective matrices with factors that fully capture and augment regeneration. This patent, the ones following, and our current portfolio effectively differentiate CorMatrix from other regenerative companies.”

“The issuance of U.S. Patent No. 8,568,761 is a significant milestone in our patent prosecution efforts,” said David B. Camp, chairman and CEO of CorMatrix . “Having a priority date of 2005 establishes CorMatrix as the leader in the field of cardiovascular regenerative medicine.”

In addition to the Extracellular Matrix platform of devices already on the market in both the US and Europe, CorMatrix plans on initiating human safety trials for heart failure in Europe Q1 of 2014 with its proprietary formula and device for application of the ECM. The allowance of the U.S. Patent No. 8,568,761 broadens the already established IP file held by CorMatrix for Cardiac Tissue Repair and Heart Failure treatments.

Background of Extracellular Matrix (ECM) Biomaterial
The decellularized matrix material serves as a bioscaffold to allow vascular ingrowth from adjacent tissues to deliver progenitor cells and nutrients to the matrix, which then differentiate into tissue-specific cells and structures. The ECM material is gradually replaced as the patient’s own cells reinforces and rebuilds the diseased or damaged site. During repair, the matrix is naturally degraded and resorbed, leaving remodeled functional tissue where damaged or injured tissue would normally be expected. The safety of extracellular matrices has been well established in a number of different clinical applications and more than 500 published papers. Since 1999, an estimated two million patients worldwide have received an extracellular matrix implant.

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