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CyberKnife System Provides Relief for Trigeminal Neuralgia Patients

January 29, 2018 By Accuray Incorporated

Accuray Incorporated announced that data from a study of 138 patients with trigeminal neuralgia (TN) showed stereotactic radiosurgery (SRS) delivered with the CyberKnife System resulted in rapid and long-lasting pain relief, with minimal side effects. The study, titled “Image-Guided Robotic Radiosurgery for Trigeminal Neuralgia,” was published in the December 2017 issue of the peer-reviewed journal Neurosurgery and provides robust clinical data supporting the efficacy and safety of the system for TN patients. It is the largest single-center study of TN patients treated with the CyberKnife technology reported to date.

CyberKnife(R) System (Credit: PR Newswire)

“This study is important because it reinforces that CyberKnife SRS provides unique benefits in the treatment of TN. Pain management goals were achieved and bothersome complications were rare even though a less invasive approach to delivering radiation was used,” said Professor Pantaleo Romanelli, M.D., Centro Diagnostico Italiano, Milan, Italy. “Importantly, we used a consistent treatment protocol for each patient that resulted in reproducible outcomes. This should provide confidence to other clinicians that they, too, can achieve similar clinical results.”

TN is a disease often characterized by severe pain, with some patients describing it as the most atrocious pain human beings can suffer. Techniques like CyberKnife SRS may provide new hope for people living with this severe and challenging-to-treat medical condition.

Significant Pain Control

  • Pain relief was achieved in 93.5 percent of patients after a median delay of three weeks after treatment
  • Stable pain control was maintained by 76 percent of patients three years after the first treatment. The remainder of the patients attained pain control after a second treatment

Elimination of Pain Medication

  • 78.9 percent of patients were completely pain- and medication-free within six months after treatment
  • 93.5 percent of patients were able to decrease the dose of medications intended to control pain throughout follow-up and finally cease pain medication

Manageable Toxicity

  • Overall, 18.1 percent of patients developed some sensory disturbance. Of these patients, 68 percent experienced the onset of complications after their second treatment; this is a typical side effect following re-irradiation

“The frameless CyberKnife Robotic Radiosurgery System delivers radiation beams from multiple unique angles (non-isocentric approach) with sub-millimeter accuracy. The reproducibility of the delivery technique resulted in excellent clinical outcomes for the patients with a non-invasive technique, unlike Gamma Knife. This study confirms the long lasting effect of one single fraction treatment delivered with the CyberKnife system,” said Fabienne Hirigoyenberry-Lanson, PhD, Vice President Global Medical and Scientific Affairs, at Accuray. Importantly, the CyberKnife® technology’s unique image guidance and automatic beam correction capability enabled the precise dose targeting necessary to treat TN. No head frame was required to obtain the pain control and side effect profile achieved with Gamma Knife, as reported in other studies.1,2.

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