In September, when Carlos Monroy walked into an operating room at Español Hospital in
Mexico City, what happened next changed his life forever. He was there because he had made a small piece of plastic that would be carefully implanted onto the skull of the patient lying on the table. The patient’s name was Adriana, and when Carlos saw her the following day in the recovery room, he knew it was a success.
“Since I was little, I wanted to help people,” Carlos says. As a young student in Mexico City, he earned degrees in industrial design and aeronautical engineering before finding a job at General Electric Aviation working on aircraft engines. He then decided to move to the UK where he completed a PhD, and two post doctorates at Cambridge and Swansea University that led him to do more work in the automotive, high-performance sports, and medical device industries.
It was during this time he came up with the idea for his company, Granta, named after the stretch of river flowing through the English town where Carlos completed his studies.
Making it in Mexico
The objective of the company founded in Mexico would be to take all of the knowledge he’d gained so far in his career and channel it back into his childhood dream of helping people.
He realized his work with materials in the automotive sector, paired with some of the latest technological advancements in digital fabrication, and could be applied to medical devices.
Granta would design and fabricate customized bone implants for patients who desperately needed them. To start, they would make implants for the human skull.
“It’s the easiest place for us to start because it’s so important to protect the brain, but you don’t have any other joints or articulations,” Carlos explains. “It’s there to protect, and as long as you accomplish that, it works. For arms or hips, you have to worry about other things—you have articulating joints and many forces involved.”
“It hasn’t been easy—starting a company is difficult, and it’s even more difficult to start a company in Mexico, and even more difficult to start a company in the health sector in Mexico,” he says.
Granta was the first-ever Mexican company—and one of just six or seven companies in the world— to design custom skull implants. Right as they were opening their doors, Carlos and his team received a call from a local doctor and just like that, they had their first patient.
Coming to Adriana’s Aid
Adriana’s case was a tricky one. She had been a happy and healthy woman living in Mexico City with her husband, Jesus, before she suffered an aneurysm that put her in a life-threatening condition. After surgery to repair the injury failed, doctors told her and her family that they would need to perform a craniotomy (a procedure to remove part of her skull) in order for her brain to decompress; ultimately, a life-saving procedure.
Today there are four primary ways to perform a skull implant, or cranioplasty, to replace the bone removed during a craniotomy. The most common method is poly methyl melacrylate (PMMA) implants, which are molded during the surgery to the patient’s cranium. Unfortunately, these implants are susceptible to bacterial growth and water absorption, which can result in infection.
Another option is titanium meshes, which are expensive, fragile, and difficult to work with— meaning they can often look flat or unnatural on the patient’s skull. They’re also prone to further bending or even becoming exposed through the skin, which requires additional surgery to repair or remove the damaged areas of the implant.
There’s also grafting options, which involve harvesting bone from either the patient’s own body—a painful and lengthy process— or from a cadaver, which has a high risk of being rejected by the patient’s body.
The final option—sometimes called a decompressive craniectomy—is often considered a last resort. To allow the brain to decompress after trauma or injury, a part of the skull is removed and then surgically implanted into the patient’s abdomen to keep the skull tissue alive. Once swelling in the brain goes down, which can take up to 20 weeks—the piece of skull is then taken out of the stomach and re-implanted. Unfortunately, the skull tissue often dies before the final transplant can be performed, making this a high-risk option.
With Granta, Carlos knew that he could provide a fifth option that would be safer, easier to install surgically, and more natural-looking for the patient. But he also knew that choosing the right set of tools to design, prototype, engineer, and manufacture the implants was critical. That’s when he reached out to the Autodesk Foundation. They helped Carlos and his team to find the right solutions to design the implants.
Adriana’s initial cranioplasty was performed using a PMMA implant. She seemed to be recovering well before a secondary infection occurred, which led to a buildup of fluid under the implant that damaged it to the point that emergency surgery was performed to remove it.
Once again, Adriana found herself in a precarious state, and it wasn’t just affecting her physical health. It took a huge emotional toll on her and her family. She did not feel, or look, like the woman that she once was. This is a common hardship for people who suffer trauma to the skull. Their self-esteem is impacted by their changed appearance, making it difficult to lead a regular life, or even keep their job.
Adriana’s family was becoming more and more concerned, and by the time they were put in touch with Carlos, the situation was serious.
Customized with Care (and CAD)
After receiving Adriana’s case, Carlos and his team immediately got to work. They had a full suite of Autodesk software at their disposal and made good use of it. After receiving a CT scan from her doctor, they converted it to point cloud data and used Autodesk Netfabb to clean and prepare the file before bringing it into 3D design software like Autodesk Inventor or Fusion 360.
Working from the 3D model, they designed a custom implant that would fit to the exact size and shape of Adriana’s skull. They shared the digital file and a 3D printed prototype with the surgeon, who then provided feedback about any modifications that needed to be made. Once the design was finalized, the team manufactured the implant out of PEEK (polyethyl ethyl ketone), a polymer that’s more biocompatible and less prone to infection—a much safer option than traditional acrylic implants.
Granta used Autodesk Powermill to machine the material with a 5-axis CNC to exactly match the 3D model. Since the implant needed to be a perfect replica of the design, the team 3D scanned it with Autodesk ReCap, which creates a virtual model of the physical part that they can then compare to the original 3D design. Everything matched up, so in September of 2018 the implant was then shipped to the hospital to be prepared for Adriana’s surgery.
A traditional cranioplasty can take upward of six hours to perform because the neurosurgeon has to spend a significant amount of time molding and shaping the implant—whether it’s made from acrylic, titanium or bone graft—to fit the patient’s skull. The longer a surgery takes, the more likely it is for infection to occur because during the procedure the patient’s tissue is exposed to possible contaminants in the environment.
With Granta’s implant, the surgeon was able to easily (and carefully) place it onto Adriana’s skull for a perfect fit. It took only four minutes—something the operating team had never before experienced.
“At that point everything became so real,” Carlos recounts. “Being able to see the implant being fit, being fixed to her skull in less than four minutes, and perfectly without any complications, and they closed it, and when we went out from the surgery room I couldn’t believe it. Everything made sense.”
The next day, Carlos went to meet Adriana in recovery. “She received me with a huge smile, and said, ‘Thank you for what you have done for me, you have changed my life.’ And in reality, it’s the other way around. I mean the way she changed my life is something that I will always be grateful to her for.”