Medical Design and Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech

Drug-Eluting Material Aims to Curb SSIs

April 26, 2016 By Sam Brusco

Bacteria associated with mesh surgical site infections, like MRSA and E. coli, are both a threat to patient health and patient wallets. Among one of the riskier surgeries that use a mesh is ventral hernia repair, which can often result in high rates of infection.

The proliferation of these surgical site infections presented a need to develop a strategy for a new type of antimicrobial mesh. One such company developed a drug-eluting mesh that aims to prevent implantable surgical devices’ contamination by hitting a targeted area with bacteria-killing agents. In order to gain more insight on the mesh’s development, MDT spoke with Dr. Lisa Jennings, co-founder and chief scientific officer of Ariste Medical, the company that developed the mesh.

Dr. Jennings presenting the technology at the AHS in April 2016 in Washington, D.C.

What problem is the new antimicrobial graft addressing?

Dr. Jennings: Ariste’s technology is poised to drastically reduce bacterial colonization of surgical implants that are so often devastating to patients and care providers. In addition to infection, restenosis and thrombosis are common complications that lead to device failure. 

Why ventral hernia repair as the first application?

Dr. Jennings: With more than 350,000 ventral hernia procedures performed annually, open ventral hernia repair is among the most common surgeries in the United States, but often results in high rates of infection, excess morbidity and healthcare expenses. As our technology can greatly reduce these unfortunate outcomes, we felt we could have the greatest impact by first aiming to improve the hernia repair procedure.

Additionally, there is an obvious clinical need with the reported rates of infection particularly in patients that are obese, chronic smokers, or that suffer from uncontrolled diabetes or repeat hernia repair procedures. In addition, with the increased scrutiny of the biologic meshes in terms of infection rates, a new alternative is necessary.

How do antimicrobial “synthetics” succeed where biologics fail? (Why polypropylene?)

Dr. Jennings: Most of the earlier products were either soaked or dip-coated with anti-microbial agents. Ariste’s technology, the first polypropylene coated antimicrobial graft for open ventral hernia repair, provides a programmed drug-elution profile that may include a burst release, a near-linear release of drug, and a gradual elution over the course of at least 14 days. While infection may be evident within days of a surgical procedure, other signs of infection may be much longer, even weeks after open ventral hernia repair. Our timeframe may have added benefit in preserving the implant and inhibiting bacterial colonization of the mesh. Our initial mesh will be polypropylene since it is the most common mesh material used by physicians for ventral hernia repair.

Beyond hernia repair, what other potential applications might the mesh have?

Dr. Jennings: We are not limited to a certain implantable material or drug combination. We anticipate making a significant impact in alleviating complications due to device implantation such as infection, scar tissue formation or clotting.

Related Articles Read More >

Lazurite ArthroFree wireless surgical camera system Minnetronix Medical
How Minnetronix Medical helped Lazurite with its wireless surgical camera
Medtronic Hugo robot-assisted surgery system
The road to a robot: Medtronic’s development process for its Hugo RAS system
A portrait of Stryker executive Siddarth Satish
How Stryker includes users for product design in the digital age
A portrait of Stryker executive Tracy Robertson
Stryker leaders talk medtech trends at DeviceTalks Boston: ‘If you’re slow, you’re going to lose’

DeviceTalks Weekly.

May 13, 2022
Our Pre-Post-DeviceTalks Boston episode, also MedtronicTalks replay with Gastro CMO Austin Chiang
See More >

MDO Digital Edition

Digital Edition

Subscribe to Medical Design & Outsourcing. Bookmark, share and interact with the leading medical design engineering magazine today.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
DeviceTalks

DeviceTalks is a conversation among medical technology leaders. It's events, podcasts, webinars and one-on-one exchanges of ideas & insights.

DeviceTalks

New MedTech Resource

Medical Tubing

Enewsletter Subscriptions

Enewsletter Subscriptions

MassDevice

Mass Device

The Medical Device Business Journal. MassDevice is the leading medical device news business journal telling the stories of the devices that save lives.

Visit Website
MDO ad
Medical Design and Outsourcing
  • MassDevice
  • DeviceTalks
  • MedTech 100 Index
  • Medical Tubing + Extrusion
  • Drug Delivery Business News
  • Drug Discovery & Development
  • Pharmaceutical Processing World
  • R&D World
  • About Us/Contact
  • Advertise With Us
  • Subscribe to Print Magazine
  • Subscribe to E-newsletter
  • Attend our Monthly Webinars
  • Listen to our Weekly Podcasts
  • Join our DeviceTalks Tuesdays Discussion

Copyright © 2022 WTWH Media, LLC. All Rights Reserved. Site Map | Privacy Policy | RSS

Search Medical Design & Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech