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EEG Could Show Awareness of Person in Vegetative State

July 27, 2016 By University of Birmingham

New research suggests that an electroencephalogram (EEG) could be a strong indicator of the level of awareness of patients in a vegetative state after a severe brain injury.

Functional magnetic resonance imaging (fMRI) has repeatedly shown that a significant minority of patients diagnosed as in the vegetative state are actually aware, but unable to show it reliably with their behavior.

The new research findings, published in Annals of Neurology, suggest a correspondence between a patient’s ability to generate an EEG marker of attention to tactile stimulation, and their ability to produce the critical clinical marker of awareness by following verbal commands.

Crucially, this relationship existed for patients who could only follow commands with the more expensive methods of fMRI.

The mental demands of the EEG task are lower than the demands of the fMRI tasks. Furthermore, EEG is entirely portable, inexpensive, and available in the majority of hospitals.

The researchers state that this simpler EEG assessment may be capable of diagnosing a patient’s level of awareness without the need for expensive and challenging fMRI scans, thereby increasing the number of patients who may benefit from a more accurate diagnosis.

Fourteen patients were selected for the study, across levels of awareness and behavioral ability; seven in a vegetative state, four in a minimally conscious state, two emerging from a minimally conscious state, and one with locked in syndrome.

Each patient’s surrogate decision maker provided informed, written consent for the patient’s participation in the study. As a scientific control, a sample of fifteen healthy volunteers also participated in the tasks.

The patients completed two sets of brain imaging tasks:

  • Vibrating stimulators affixed to each wrist and the upper back administered non-painful pulses five times per second while the patients’ EEGs were recorded. 80 percent of these vibrations occurred on the upper back. The relatively more infrequent vibrations on the wrists (20 percent of the time) produce changes in a healthy individual’s EEG that reflect attention being drawn toward the new location of stimulation.
  • During separate fMRI scans, patients were asked to engage in three established measures of a covert ability to follow commands: imagining playing tennis, imagining walking around the house, and counting target words in a stream of distractors.

All patients whose EEGs showed evidence of attention being directed toward the infrequent tactile stimuli were also able to display evidence of following commands in the fMRI tasks.

Similarly, most patients (five of six) who did not generate a response to the EEG task did not generate evidence of command following.

“The ultimate aim is to provide more accurate diagnoses for all patients, thus directing appropriate rehabilitation and therapy to those most likely to benefit,” said Dr. Damian Cruse, from the University of Birmingham.

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