Medical Design and Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Supplies and Components Index
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • MedTech Resources
    • Medtech Events in 2025
    • The 2024 Medtech Big 100
    • Medical Device Handbook
    • MedTech 100 Index
    • Subscribe to Print Magazine
    • DeviceTalks
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Podcasts
    • Print Subscription
    • Webinars / Digital Events
    • Whitepapers
    • Voices
    • Video
  • 2025 Leadership
    • 2024 Winners
    • 2023 Winners
    • 2022 Winners
    • 2021 Winners
  • Women in Medtech
  • Advertise
  • Subscribe

Electrical Implant Reduces ‘Invisible’ Symptoms Of Man’s Spinal Cord Injury

February 22, 2018 By University of British Columbia

An experimental treatment that sends electrical currents through the spinal cord has improved “invisible” yet debilitating side effects for a B.C. man with a spinal cord injury.

A diving accident six years ago left Isaac Darrel, of Langley, British Columbia, with a spinal cord injury. Side effects of the injury include dizziness, fluctuations in blood pressure, and changes in bladder and bowel function.

Darrel made the decision to have electrodes surgically implanted over his spinal cord in 2016 to test out a treatment known as epidural stimulation in the hopes of improving some of the side effects. A case study about his experiences was published today in JAMA Neurology.

“Mobility issues or paralysis are the most visible consequences of a spinal cord injury but as a clinician, I know that many of my patients suffer from other ‘invisible’ consequences,” says Dr. Andrei Krassioukov, principal investigator of the study who worked with Darrel for a number of years as a professor of medicine at UBC and chair in rehabilitation research with ICORD, a Vancouver research centre focused on spinal cord injuries.

“Many of my patients have abnormal blood pressure and bladder, bowel and sexual dysfunctions that can be quite devastating.”

Epidural stimulation involves surgically inserting electrodes permanently above the spinal cord and then stimulating the nerve cells in the spinal cord with electrical currents. The therapeutic benefits of epidural stimulation have been well-documented for chronic back pain, but a small number of experimental trials are testing the treatment on people with spinal cord injuries.

(Image credit: screen grab from University of British Columbia video, via YouTube)

With a remote control, Darrel uses the stimulator for up to 45 minutes each day, applying different programs to transmit electrical impulses into his spinal cord that mimic the same signals that would come from the brain. The programs are designed to stimulate specific nerves that help with various motor functions, but Darrel and Krassioukov have observed other positive changes.

Before the treatment, Darrel said he often felt light-headed, especially when he moved from his bed to his wheelchair or during exercise, and his blood pressure would drop.

“My blood pressure would tank right down into the 60s,” says Darrel, who describes feeling nauseous and like the world was spinning. “I would pass out or black out sitting in my chair sometimes. Now, since I have the implant, I’m able to turn up the stimulation enough that it makes it impossible for me to black out.”

The symptoms Darrel experienced are part of a disorder known as orthostatic hypotension, resulting from poor cardiovascular function. Since the surgery, a team of researchers at ICORD have been following Darrel’s case and running tests to determine how his cardiovascular function has changed. Using something called a tilt table, they put patients into an upright position to see if they are able to maintain their blood pressure.

“If there is no drop in arterial blood pressure, it is considered normal,” says Krassioukov. “It means the person has good control of blood vessels in their lower extremities and the abdomen.”

The stimulator has improved Darrel’s ability to control his blood pressure as well as other benefits.

“I’ve had better blood pressure, better core muscle, much improved bowel function, and basically I have more energy,” says Darrel, who noted that this means he can now sit in his wheelchair for up to eight hours, a big improvement from the two hours he could endure prior to the surgery.

The results point to the need to fully understand how this treatment could be used in clinical settings. Krassioukov and his colleagues are currently collaborating with colleagues in the U.S. on a larger trial, examining the benefits of epidural stimulation on a bigger group. They are also involved in research on a similar but non-invasive version of the treatment that involves stimulating the spinal cord with a device positioned on top of the skin at the University of California, Los Angeles.

“We see very interesting and exciting results but as a clinician-scientist, I need more robust data before I would recommend this procedure,” he says.

Related Articles Read More >

This is a Zimmer Biomet marketing image of its Rosa robotic surgery system.
Zimmer Biomet seeks a ZBEdge for its Rosa robotic surgery
A photo of Capstan Medical's mitral valve implant, which uses nitinol.
Capstan Medical’s R&D head discusses the heart valve and robotics startup’s tech, engineering challenges and solutions, advice for others in medtech and how to join his team
An illustration of a neurosurgeon using a robotic endoscope to remove a brain tumor.
MDO Nitinol Innovation Special Report
A photo of Highridge Medical CEO Rebecca Whitney.
Highridge Medical is betting on this spine tech
“mdo
EXPAND YOUR KNOWLEDGE AND STAY CONNECTED
Get the latest medical device business news, application and technology trends.

DeviceTalks Weekly

See More >

MDO Digital Edition

Digital Edition

Subscribe to Medical Design & Outsourcing. Bookmark, share and interact with the leading medical design engineering magazine today.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
DeviceTalks

DeviceTalks is a conversation among medical technology leaders. It's events, podcasts, webinars and one-on-one exchanges of ideas & insights.

DeviceTalks

New MedTech Resource

Medical Tubing

MassDevice

Mass Device

The Medical Device Business Journal. MassDevice is the leading medical device news business journal telling the stories of the devices that save lives.

Visit Website
MDO ad
Medical Design and Outsourcing
  • MassDevice
  • DeviceTalks
  • MedTech100 Index
  • Medical Tubing + Extrusion
  • Medical Design Sourcing
  • Drug Delivery Business News
  • Drug Discovery & Development
  • Pharmaceutical Processing World
  • R&D World
  • About Us/Contact
  • Advertise With Us
  • Subscribe to Print Magazine
  • Subscribe to our E-Newsletter
  • Listen to our Weekly Podcasts
  • Join our DeviceTalks Tuesdays Discussion

Copyright © 2025 WTWH Media, LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media LLC. Site Map | Privacy Policy | RSS

Search Medical Design & Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Supplies and Components Index
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • MedTech Resources
    • Medtech Events in 2025
    • The 2024 Medtech Big 100
    • Medical Device Handbook
    • MedTech 100 Index
    • Subscribe to Print Magazine
    • DeviceTalks
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Podcasts
    • Print Subscription
    • Webinars / Digital Events
    • Whitepapers
    • Voices
    • Video
  • 2025 Leadership
    • 2024 Winners
    • 2023 Winners
    • 2022 Winners
    • 2021 Winners
  • Women in Medtech
  • Advertise
  • Subscribe