Medical Design and Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech

How the body’s inflammatory response could repair a damaged heart

April 30, 2019 By Danielle Kirsh

human-heart

[Image from Wikipedia]

Northwestern University and University of California San Diego researchers have designed a minimally invasive platform that delivers a nanomaterial to turn the body’s inflammatory response into a healing signal.

The research team has developed a way to deliver a bioactivated, biodegradable, regenerative substance without clogging through a noninvasive catheter. The method was tested in rat models.

“This research centered on building a dynamic platform, and the beauty is that this delivery system now can be modified to use different chemistries or therapeutics,” Nathan Gianneschi, a professor of chemistry at Northwestern University and a researcher on the project, said in a press release.

When a heart attack occurs, the heart’s extracellular matrix is destroyed and scar tissue begins to form. Scar tissue can decrease the functionality of the heart. Most heart attack survivors will develop heart disease, which is the leading cause of death in the U.S.

“We sought to create a peptide-based approach because the compounds form nanofibers that look and mechanically act very similar to native extracellular matrix. The compounds also are biodegradable and biocompatible,” Andrea Carlini, first author on the research, said. “Most preclinical strategies have relied on direct injections into the heart, but because this is not a feasible option for humans, we sought to develop a platform that could be delivered via intracoronary or transendocardial catheter.”

The healing method is assisted by self-assembling peptides that are delivered through a catheter to the heart following a heart attack.

“What we’ve created is a targeting-and-response type of material,” Gianneschi, associate director of Northwestern’s International Institute of Nanotechnology, said. “We inject a self-assembling peptide solution that seeks out a target – the heart’s damaged extracellular matrix – and the solution is then activated by the inflammatory environment itself and gels. The key is to have the material create a self-assembling framework, which mimics the natural scaffold that holds cells and tissues together.”

The method was tested in two proof-of-concept tests. The first test showed that the peptide material can be fed through a catheter without clogging and without interacting with human blood. The second test determined if the self-assembling peptides can find damaged tissue to heal it without interfering with healthy heart tissue. The researchers attached a fluorescent tag that they created to the peptides and imaged the heart to see where the peptides end up.

“In previous work with responsive nanoparticles, we produced speckled fluorescence in the heart attack region, but in this case, we were able to see large continuous hydrogel assemblies throughout the tissue,” Carlini said.

The researchers then removed the fluorescent tags and replaced it with a therapeutic that allows the peptides to locate the damaged part of the heart. The researchers say that the process of getting to clinical trial could take several years.

“We started working on this chemistry in 2012, and it took immense effort to produce a modular and synthetically simple platform that would reliably gel in response to the inflammatory environment,” Carlini said. “A major breakthrough occurred when we developed statically constrained cyclic peptides, which flow freely during delivery and then rapidly assemble into hydrogels when they come in contact with disease-associated enzymes.”

Carlini and the researchers programmed a spring-like switch to unfurl naturally circular compounds and create a flat substance with more surface area and better adhesiveness. The switch allows the peptides to self-assemble better to form the scaffolding that most looks like the native extracellular matrix.

The research was published in the journal Nature Communications.

Related Articles Read More >

Logos of Creo Medical and Intuitive
Creo Medical inks collaboration agreement with Intuitive
A portrait of Dr. Philip Adamson
Expect more heart and lung failure years after COVID, Abbott’s heart failure CMO says
Lazurite ArthroFree wireless surgical camera system Minnetronix Medical
How Minnetronix Medical helped Lazurite with its wireless surgical camera
Medtronic Hugo robot-assisted surgery system
The road to a robot: Medtronic’s development process for its Hugo RAS system

DeviceTalks Weekly.

May 20, 2022
DeviceTalks Boston Post-Game – Editors’ Top Moments, Insulet’s Eric Benjamin on future of Omnipod 5
See More >

MDO Digital Edition

Digital Edition

Subscribe to Medical Design & Outsourcing. Bookmark, share and interact with the leading medical design engineering magazine today.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
DeviceTalks

DeviceTalks is a conversation among medical technology leaders. It's events, podcasts, webinars and one-on-one exchanges of ideas & insights.

DeviceTalks

New MedTech Resource

Medical Tubing

Enewsletter Subscriptions

Enewsletter Subscriptions

MassDevice

Mass Device

The Medical Device Business Journal. MassDevice is the leading medical device news business journal telling the stories of the devices that save lives.

Visit Website
MDO ad
Medical Design and Outsourcing
  • MassDevice
  • DeviceTalks
  • MedTech 100 Index
  • Medical Tubing + Extrusion
  • Drug Delivery Business News
  • Drug Discovery & Development
  • Pharmaceutical Processing World
  • R&D World
  • About Us/Contact
  • Advertise With Us
  • Subscribe to Print Magazine
  • Subscribe to E-newsletter
  • Attend our Monthly Webinars
  • Listen to our Weekly Podcasts
  • Join our DeviceTalks Tuesdays Discussion

Copyright © 2022 WTWH Media, LLC. All Rights Reserved. Site Map | Privacy Policy | RSS

Search Medical Design & Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech