Medical Design and Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech

IBS Creates a wearable graphene-based biomedical device to monitor and combat diabetes

March 22, 2016 By Nic Abraham

Optical image of the GP-hybrid electrochemical device array on the human skin.

Optical image of the GP-hybrid electrochemical device array on the human skin.

A scientific team from the Center for Nanoparticle Research at IBS has created a wearable GP-based patch that allows accurate diabetes monitoring and feedback therapy by using human sweat. The researchers improved the device’s detecting capabilities by integrating electrochemically active and soft functional materials on the hybrid of gold-doped graphene and a serpentine-shape gold mesh. The device’s pH and temperature monitoring functions enable systematic corrections of sweat glucose measurements as the enzyme-based glucose sensor is affected by pH (blood acidity levels) and temperature.

Diabetes and regulating glucose levels

Insulin is produced in the pancreas and regulates the use of glucose, maintaining a balance in blood sugar levels. Diabetes causes an imbalance: insufficient amounts of insulin results in high blood glucose levels, known as hyperglycemia. Type 2 diabetes is the most common form of diabetes with no known cure. It affects some 3 million Koreans with the figure increasing due to dietary patterns and an aging society. The current treatments available to diabetics are painful, inconvenient and costly; regular visits to a doctor and home testing kits are needed to record glucose levels. Patients also have to inject uncomfortable insulin shots to regulate glucose levels. There is a significant need for non-invasive, painless, and stress-free monitoring of important markers of diabetes using multifunctional wearable devices. The IBS device facilitates this and thereby reduces the lengthy and expensive cycles of visiting doctors and pharmacies.

Components of the graphene-based wearable device

KIM Dae-Hyeong, a scientist from the Center for Nanoparticle Research, describes the vast array of components: “Our wearable GP-based device is capable of not only sweat-based glucose and pH monitoring but also controlled transcutaneous drug delivery through temperature-responsive microneedles. Precise measurement of sweat glucose concentrations are used to estimate the levels of glucose in the blood of a patient. The device retains its original sensitivity after multiple uses, thereby allowing for multiple treatments. The connection of the device to a portable/ wireless power supply and data transmission unit enables the point-of-care treatment of diabetes.” The professor went on to describe how the device works, “The patch is applied to the skin where sweat-based glucose monitoring begins on sweat generation. The humidity sensor monitors the increase in relative humidity (RH). It takes an average of 15 minutes for the sweat-uptake layer of the patch to collect sweat and reach a RH over 80% at which time glucose and pH measurements are initiated.”

Merits of the device and drug administration

The device shows dramatic advances over current treatment methods by allowing non-invasive treatments. During the team’s research, two healthy males participated in tests to demonstrate the sweat-based glucose sensing of the device. Glucose and pH levels of both subjects were recorded; a statistical analysis confirmed the reliable correlation between sweat glucose data from the diabetes patch and those from commercial glucose tests. If abnormally high levels of glucose are detected, a drug is released into a patient’s bloodstream via drug loaded microneedles. The malleable, semi-transparent skin-like appearance of the GP device provides easy and comfortable contact with human skin, allowing the sensors to remain unaffected by any skin deformations. This enables stable sensing and efficient drug delivery.

The scientific team also demonstrated the therapeutic effects by experimenting on diabetic (db/db) mice. Treatment began by applying the device near the abdomen of the db mouse. Microneedles pierced the skin of the mouse and released Metformin, an insulin regulating drug, into the bloodstream. The group treated with microneedles showed a significant suppression of blood glucose concentrations with respect to control groups. “One can easily replace the used microneedles with new ones. Treatment with Metformin through the skin is more efficient than that through the digestive system because the drug is directly introduced into metabolic circulation through the skin,” commented KIM Dae-Hyeong. He went on: “These advances using nanomaterials and devices provide new opportunities for the treatment of chronic diseases like diabetes.”

Institute for Basic Science
mdanderson.org

Related Articles Read More >

Dexcom One
How Dexcom’s portfolio goes beyond highly-anticipated next-gen G7
An illustration of a cloud-shaped room filled with medical devices
The cloud is transforming medtech: Amazon, Microsoft, Google, J&J, Philips and GE Healthcare leaders explain
Caretaker Medical VitalStream
FDA clears four new parameters for Caretaker Medical’s wireless patient monitoring system
A roll of medical tape
3M launches 21-day adhesive skin tape for medical devices

DeviceTalks Weekly.

May 13, 2022
Our Pre-Post-DeviceTalks Boston episode, also MedtronicTalks replay with Gastro CMO Austin Chiang
See More >

MDO Digital Edition

Digital Edition

Subscribe to Medical Design & Outsourcing. Bookmark, share and interact with the leading medical design engineering magazine today.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
DeviceTalks

DeviceTalks is a conversation among medical technology leaders. It's events, podcasts, webinars and one-on-one exchanges of ideas & insights.

DeviceTalks

New MedTech Resource

Medical Tubing

Enewsletter Subscriptions

Enewsletter Subscriptions

MassDevice

Mass Device

The Medical Device Business Journal. MassDevice is the leading medical device news business journal telling the stories of the devices that save lives.

Visit Website
MDO ad
Medical Design and Outsourcing
  • MassDevice
  • DeviceTalks
  • MedTech 100 Index
  • Medical Tubing + Extrusion
  • Drug Delivery Business News
  • Drug Discovery & Development
  • Pharmaceutical Processing World
  • R&D World
  • About Us/Contact
  • Advertise With Us
  • Subscribe to Print Magazine
  • Subscribe to E-newsletter
  • Attend our Monthly Webinars
  • Listen to our Weekly Podcasts
  • Join our DeviceTalks Tuesdays Discussion

Copyright © 2022 WTWH Media, LLC. All Rights Reserved. Site Map | Privacy Policy | RSS

Search Medical Design & Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech