Cancer Research UK scientists have used imaging techniques as a new way to identify patients who could benefit from certain breast cancer treatments, according to a study published in Oncotarget.
The team at King’s College London, in collaboration with scientists at the CRUK/MRC Oxford Institute for Radiation Oncology, used fluorescence lifetime imaging, a technique that can accurately measure the distance between two protein molecules. In the study, the distance between HER2 and HER3 proteins in patient breast cancer cells was measured.
The researchers think that patients whose imaging results show that these proteins have bonded together could benefit from HER2 targeted treatment, regardless of whether their tumor has high levels of HER2.
HER2 is a protein which can cause cancer cells to grow. HER2-positive breast cancer cells have high levels of the protein and can be targeted with drugs that block its effects and stop the cancer from growing – drugs being used now include Herceptin and Tykerb.
The left image is a tissue sample with low levels of HER2 and HER3 bonded together. The right is a sample with high levels. (Credit: Cancer Research UK)
Patients who could benefit from these drugs are identified by testing their cancer cells to see if they show high levels of the HER2 protein.
But this imaging technique, carried out in tumor cells, could pick up additional patients in the future who would respond well to HER2-targeting drugs. It could also confirm which patients may not be suitable for these treatments.
“This imaging technique could help us pick up patients who might benefit from these drugs but have previously been overlooked,” lead author Tony Ng of King’s College London and University College London, said. “Using this test, we should be able to predict which drugs won’t work in patients and avoid prescribing unnecessary treatments – putting the drugs that we’ve got to better use. The next step is to run clinical trials to see if this test could help patients.”
He added that one day the imaging technique for breast cancer also might improve treatment for bowel, lung and other cancers.