Medical Design and Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • Subscribe to Print Magazine
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech

Implantable Microscope Allows Deep Brain Exploration

May 12, 2015 By University of Colorado Denver

A team of neuroscientists and bioengineers at the University of Colorado Anschutz Medical Campus have created a miniature, fiber-optic microscope designed to peer deeply inside a living brain.

The researchers, including scientists from the University of Colorado Boulder, published details of their revolutionary microscope in the latest issue of Optics Letters journal.

 

“Microscopes today penetrate only about one millimeter into the brain but almost everything we want to see is deeper than that,” said Prof. Diego Restrepo, PhD, one of the paper’s authors and director of the Center for NeuroScience at CU Anschutz. “You can manipulate this lens while most others are fixed. That means you can see neurons firing inside a living brain.”

The laser-scanning microscope, a prototype which will be further refined, uses fiber-optics and a tiny electrowetting lens. Compared to other small, focusing lenses, it’s fast and not sensitive to motion. This allows it to reliably focus on living tissue.

At the same time, the lens allows a rapid shifting of focus by applying electricity across two different liquids, which actually changes the curvature of lens.

The microscope, about half an inch in diameter, can be directly mounted onto the head of a mouse. A thin, fiber optic cord will allow the animal to freely roam while scientists look inside its brain and monitor reactions to certain stimuli.

That means parts of the living brain like the amygdala, which had been virtually off-limits to microscopes, will soon be seen in real-time, high-resolution, 3D images.

“Using optical methods to stimulate and record from neurons is the future of neuroscience research,” said Baris Ozbay, a doctoral student in bioengineering at CU Anschutz and lead author of the paper. “But most researchers are adapting existing large microscopes to fit mice for head-fixed imaging which limits movement, is difficult to set up and has issues with motion. The solution is to put the microscope on the mouse, rather than putting the mouse on the microscope.”

Emily Gibson, PhD, assistant professor of bioengineering at CU Anschutz and senior author of the study, said the microscope opens a new world for scientists.

“We can now measure a large region and sample more neurons,” she said. “For example, we can image up to 100 neurons at the same time, as opposed to perhaps the 10 or so we could do in the past.”

All of this has potential human applications as well.

“The ability to see beneath the surface of the brain offers new, powerful ways to study brain function,” said Restrepo, a professor of cell and developmental biology. “It will help us understand brain disease and formulate new treatments.”

Other possibilities include:

  • Screening pharmaceuticals targeted to specific brain disorders.
  • Allowing neurosurgeons to image small brain areas like those targeted in the treatment of Parkinson’s disease.
  • Conducting optical, in situ, biopsies for diagnosis of brain tumors.
  • Examining the connection between neural damage and controlling prosthetic limbs.

Research was made possible by a $1 million grant from the National Science Foundation.

Related Articles Read More >

A portrait of Ellen Roche, MIT School of Engineering associate professor
New implant design prevents scar tissue without drugs, MIT says
UMN artificial blood vessel clinical trial
Minnesota researchers awarded $3.7M grant for artificial, bioengineered blood vessel clinical trial
CeQur Simplicity
CeQur is launching a discreet, convenient ‘wearable insulin pen’
Blackrock's Utah array is a miniature array of electrodes for sensing brain signals
Blackrock Neurotech and Pitt work on first at-home BCI system for remote trials

DeviceTalks Weekly.

August 5, 2022
DTW Medtronic's Greg Smith lays out supply chain strategies
See More >

MDO Digital Edition

Digital Edition

Subscribe to Medical Design & Outsourcing. Bookmark, share and interact with the leading medical design engineering magazine today.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
DeviceTalks

DeviceTalks is a conversation among medical technology leaders. It's events, podcasts, webinars and one-on-one exchanges of ideas & insights.

DeviceTalks

New MedTech Resource

Medical Tubing

Enewsletter Subscriptions

Enewsletter Subscriptions

MassDevice

Mass Device

The Medical Device Business Journal. MassDevice is the leading medical device news business journal telling the stories of the devices that save lives.

Visit Website
MDO ad
Medical Design and Outsourcing
  • MassDevice
  • DeviceTalks
  • MedTech100 Index
  • Medical Tubing + Extrusion
  • Medical Design Sourcing
  • Drug Delivery Business News
  • Drug Discovery & Development
  • Pharmaceutical Processing World
  • R&D World
  • About Us/Contact
  • Advertise With Us
  • Subscribe to Print Magazine
  • Subscribe to E-newsletter
  • Attend our Monthly Webinars
  • Listen to our Weekly Podcasts
  • Join our DeviceTalks Tuesdays Discussion

Copyright © 2022 WTWH Media, LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media LLC. Site Map | Privacy Policy | RSS

Search Medical Design & Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • Subscribe to Print Magazine
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech