Macular degeneration recreated on a chip


age-related macular degeneration

Fundus photograph of wet-type age-related macular degeneration. [Image from Tohoku University]

Tohoku University researchers say they’ve recreated retinal diseases such as macular degeneration on a chip for disease modeling and drug screening.

A research team from the Graduate Schools of Engineering and Medicine at Tohoku University cultured human retinal cells and vascular endothelial cells to replicate the outermost structure of the retina.

Retinal cells exposed to hypoglycemic and hypoxic conditions after maturity allowed endothelial cells to move to the side of retinal cells which would damage them. The whole process repeats neovascularization in age-related macular degeneration.

Age-related macular degeneration is an eye condition that is the leading cause of vision loss in people older than 50. It causes damage to the macula at the center of the retina, blurring the sharp, central vision needed for straight ahead activities like driving, according to the National Eye Institute.

Organ-on-a-chip technology is fairly new and ocular organs-on-a-chip have rarely been tested. These in vitro cell culture models eliminate the need for animal models while allowing researchers to study specific molecules-of-interest and recreate chronic and complex diseases.

The research team thinks that the recreation of age-related macular degeneration on a chip will help with disease modeling and will completely eliminate the need for animal models, which often comes into question because of the ethics of it.

[Want to stay more on top of MDO content? Subscribe to our weekly e-newsletter.]

Don't Miss the Most Anticipated Conference of the Fall!

textadimage DeviceTalks Boston is just a few months away. More than 50 speakers and 35 exhibitors will join over 400 members of this red-hot industry, for a look inside the most important developments facing our community.

Join us for three days of world-class education, networking, and a technology exhibition featuring the leading companies in the industry.

Take a look at our speaker line-up and more.

Speak Your Mind