As the world’s biggest medical device companies get bigger, that makes it harder for companies to make our Medtech Big 100 ranking each year.

The annual revenue needed to get onto the list at the No. 100 spot keeps climbing each year. This year’s No. 100 company had annual revenue of $354 million, $40 million higher than last year’s No. 100 and nearly $118 million higher than the year before that.

However, companies that just miss making the Medtech Big 100 often find themselves on the list the following year. For example, this year’s No. 99 — Axonics — was No. 104 last year and now has a deal to be acquired by Boston Scientific, No. 11 on our list.

With that in mind, here are the companies that would have ranked Nos. 101 to 105 on this year’s list.

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