Medical Design and Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech

New Insights Provide Promise for Development of Tools to Protect Damaged Tissues

September 13, 2010 By Bio-Medicine.Org

MEMPHIS, Tenn., Sept. 13 /PRNewswire-USNewswire/ — St. Jude
Children’s Research Hospital investigators have identified a novel
structure in cells that serves as a control switch in the body’s
system for eliminating damaged cells and also offers new
therapeutic potential.

The findings provide fresh insight into the machinery at work as
cells ramp up production of p53 protein following DNA damage. The
p53 protein plays a critical role in how cells respond to the
stress that damages DNA. The gene that carries instructions for
making p53 protein is the most commonly mutated gene in human
cancers.

Investigators also identified molecules that disrupt the system
and reduce p53 protein levels in cells damaged by irradiation or
chemotherapy. These small molecules helped cells growing in the
laboratory survive better after they were damaged. The findings
appear in the September 13 online edition of the journal Genes
& Development
.

The work lays the foundation for a new approach to protecting
healthy tissue using small molecules to reduce p53 protein levels
in cells following damage caused by a wide range of factors,
including the radiation and chemotherapy used to treat cancer or
accidental exposure to dangerous chemicals or radiation, said
Michael Kastan, M.D., Ph.D., director of the St. Jude Comprehensive
Cancer Center and the paper’s senior author. The same approach
might also help ease the tissue damage that occurs as blood flow
and oxygen are restored following a heart attack or stroke.

“We are excited about this because we now theoretically have a
way of blunting p53 induction in settings where it is detrimental,”
he said.

The work builds on previous research from Kastan’s laboratory
into the mechanics of how p53 protein increases in response to
cellular stress and DNA damage. Jing Chen, Ph.D., a postdoctoral
fellow in Kastan’s laboratory, is first author of the study.

The jump in p53 protein production was wide

‘/>”/>

SOURCE

Related Articles Read More >

Johnson & Johnson Office of Digital Innovation Leader Peter Schulam
Imagining the future of cloud-connected medical devices with Johnson & Johnson leaders
Withings Body Scan
Withings plans launch for Body Scan smart scale platform
BinaxNow COVID-19 Ag Card
Time recognizes Abbott offerings among this year’s 100 best inventions
Koya Medical’s Dayspring device
Koya Medical reports positive early results in Dayspring lymphedema trial

DeviceTalks Weekly.

May 27, 2022
Quick message - No DTW podcast, but plenty else to listen to over this weekend and next week.
See More >

MDO Digital Edition

Digital Edition

Subscribe to Medical Design & Outsourcing. Bookmark, share and interact with the leading medical design engineering magazine today.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
DeviceTalks

DeviceTalks is a conversation among medical technology leaders. It's events, podcasts, webinars and one-on-one exchanges of ideas & insights.

DeviceTalks

New MedTech Resource

Medical Tubing

Enewsletter Subscriptions

Enewsletter Subscriptions

MassDevice

Mass Device

The Medical Device Business Journal. MassDevice is the leading medical device news business journal telling the stories of the devices that save lives.

Visit Website
MDO ad
Medical Design and Outsourcing
  • MassDevice
  • DeviceTalks
  • MedTech 100 Index
  • Medical Tubing + Extrusion
  • Drug Delivery Business News
  • Drug Discovery & Development
  • Pharmaceutical Processing World
  • R&D World
  • About Us/Contact
  • Advertise With Us
  • Subscribe to Print Magazine
  • Subscribe to E-newsletter
  • Attend our Monthly Webinars
  • Listen to our Weekly Podcasts
  • Join our DeviceTalks Tuesdays Discussion

Copyright © 2022 WTWH Media, LLC. All Rights Reserved. Site Map | Privacy Policy | RSS

Search Medical Design & Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech