Proove Biosciences, Inc. announced the introduction of three new evidence-based tests to support better clinical decision-making for difficult-to-treat conditions that are influenced by genetics. Proove’s new profiles help improve outcomes for patients who are at risk for – or suffering from – substance abuse, fibromyalgia and venous thromboembolism.
“Whether it is the role of genetics in substance abuse, the confusion around understanding fibromyalgia, or the fear of venous thromboembolism for a patient undergoing orthopedic surgery, these new profiles are ultimately about facilitating better decisions to improve patient care,” said Brian Meshkin, founder and CEO of Proove Biosciences.
Proove researchers and developers have created these latest profiles to help physicians treat patients in pain, which is the nation’s largest and most expensive healthcare condition.
- With the tremendous overlap between pain, mental health and addiction, Proove’s leading bioinformatics platform has produced the Proove Addiction™ Profile to address the growing epidemic of substance abuse, which results in more than 550,000 deaths annually from alcohol, nicotine, heroin, cocaine and methamphetamines. The Proove Addiction Profile, therefore, utilizes objective genetic data to help physicians identify patients who may be at greater risk of dependence or may experience worse outcomes with substance use. Furthermore, this profile provides physicians with knowledge-based medication recommendations that can be used to guide treatment strategies for patients who are already diagnosed with substance use disorders.
- The Proove Fibromyalgia™ Profile is a first-of-its-kind decision-improvement tool that harnesses individualized information to aid in the identification of genetic factors that may contribute to differing clinical pathways behind a fibromyalgia diagnosis and in the customization of personalized treatment. The profile allows for the targeting and analysis of genetic markers that play a role in the efficacy of drug therapies designed to ameliorate the condition, which is believed to be partially caused by reduced turnover of serotonin, norepinephrine and dopamine. The test can be administered for patients who may have fibromyalgia or for those who have already been diagnosed.
- The Proove Thromboembolism™ tackles the difficulties surrounding venous thromboembolism (VTE), which is the third most common cardiovascular illness after acute coronary syndrome and stroke. Approximately one million cases occur each year, many of which represent recurrent disease. In addition to acquired risk factors, including hypertension, diabetes, smoking and high cholesterol levels, researchers have long known that genetic predisposition is a prominent risk factor for patients. This profile provides physicians with the means by which to analyze genetic variations (or polymorphisms) that are risk factors for venous thromboembolism. In addition to stratifying patients into low, moderate or high clinical probability of thromboembolic complications and enhancing the reliability of effective diagnosis, the test provides clinically actionable recommendations for prophylactic treatment.
