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Photo of the Day: Humans Risked Limb Ischemia In Exchange For Bipedal Walking

March 27, 2018 By Kumamoto University

Micro X-ray CT scans reveal the reason why mice do not suffer as much tissue damage under ischemic conditions as humans. Their inferior gluteal artery provides a more effective bridge around blood clots in the femoral artery. Credit: Dr. Yuichiro Arima

Peripheral obstructive arterial disease develops when blood vessels narrow due to arteriosclerosis and blood flow in the legs (or rarely the arms) becomes clogged. Intermittent claudication is when blood flow disturbances in a limb causes pain, numbness, or coldness during physical activity. In severe cases, where the tissue has gone without blood for too long and dies, the limb may have to be amputated.

Previous clinical and animal research showed that mice receive less tissue damage under ischemic condition than humans, but the cause of the difference was not clear. To illustrate why humans seem to have such a disadvantage, researchers from Kumamoto University, Japan focused on collateral vessels that could bypass an obstruction. Using a murine hind limb ischemia model, they compared the shape of mouse hind limb blood vessels with those of a patient who had peripheral obstructive artery disease.

For the complete story, go here.

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