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Researchers use BCIs to restore speech in people with paralysis

April 3, 2025 By Sean Whooley

UC Berkeley and UC San Diego researchers develop way to restore speech using BCIs (1)

Researchers connect the brain implant to the voice synthesizer computer. (Photo by Noah Berger/Courtesy of UC Berkeley)

A team of researchers in California say they developed a way to restore naturalistic speech for those with severe paralysis using brain-computer interfaces (BCIs).

At UC Berkeley and UC San Francisco, researchers used AI-based modeling to develop a streaming method that synthesizes brain signals into audible speech in near-real-time. The researchers say it marks a critical step toward enabling communication for people who lost the ability to speak. They published their findings in Nature Neuroscience.

In a post on UC Berkeley’s website, Goapala Anumanchipalli, assistant professor of electrical engineering and computer sciences at UC Berkeley and the study’s co-principal investigator, likened the approach to the Alexa and Siri offerings from Amazon and Apple, respectively. Using a similar type of algorithm, Anumanchipalli says, they found a way to decode neural data and enable near-synchronous voice streaming.

“The result is more naturalistic, fluent speech synthesis,” said Anumanchipalli.

Co-lead author Cheol Jun Cho, a Berkeley Ph.D student in electrical engineering and computer sciences, says the neuroprosthesis works by sampling neural data from the motor cortex, the part of the brain that controls speech production. It then uses AI to decode brain function into speech.

“We are essentially intercepting signals where the thought is translated into articulation and in the middle of that motor control,” Cho said. “So what we’re decoding is after a thought has happened, after we’ve decided what to say, after we’ve decided what words to use and how to move our vocal-tract muscles.”

In a previous BCI study, the researchers had about an eight-second latency for decoding for a single sentence. With their new approach, audible output comes through in near-real-time as the subject attempts to speak.

The researchers tested their model’s ability to synthesize words that weren’t part of the training dataset vocabulary. They say the model was successful in learning the building blocks of sound or voice.

According to the researchers, these latest developments bring them a step closer to achieving naturalistic speech with BCI devices. It also lays the groundwork for future advances.

“This proof-of-concept framework is quite a breakthrough,” said Cho. “We are optimistic that we can now make advances at every level. On the engineering side, for example, we will continue to push the algorithm to see how we can generate speech better and faster.”

About The Author

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Sean Whooley

Sean Whooley is an associate editor who mainly produces work for MassDevice, Medical Design & Outsourcing and Drug Delivery Business News. He received a bachelor's degree in multiplatform journalism from the University of Maryland, College Park. You can connect with him on LinkedIn or email him at [email protected].

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