Medical Design and Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech

Students Take Clot-Buster for a Spin

April 22, 2014 By Rice University

Rice University engineering seniors create device to break up clots in patients’ bladders 

In the hands of some Rice University senior engineering students, a fishing rod is more than what it seems. For them, it’s a way to help destroy blood clots that threaten lives.

Photos of the Day: Blood Clot Buster

Branding themselves as “Team Evacuator,” five students have been testing a device to break up blood clots that form in the bladders of adult patients and currently have to be removed by suction through a catheter in the urethra.

The urethra remains the least-invasive access to the bladder, where clots can block urine from passing and ultimately lead to kidney failure. The students’ device, which looks something like a tiny, flexible eggbeater on a stick attached to a cut-down rod and reel, is designed to fit through the catheter and break up the clots without harming the bladder wall.

The bioengineering students – Aaron Hu, Adrian Gallegos, Tiffany Huang, Patrick Yun and Lung-Ying Yu – use the modified rod to power the device for tests on simulated blood clots made with pig blood and gelatin.

The finished version will be battery-powered so it can be operated with one hand; it will turn wires at upward of 800 revolutions per minute, enough to create a vortex that pulls clots toward the spinning wires that dissolve them.

The wires are made of nitinol, a nickel-titanium alloy considered a memory metal. “It’s the same kind of metal used in braces,” Hu said. “You can deform it any way you want, but at a given temperature, it goes back to its original shape.” The wires collapse within the catheter walls and expand to their functional shape when pushed through into the bladder. “Nitinol collapses very well,” he said.

The device designed at Rice’s Oshman Engineering Design Kitchen costs about $20 in parts for the battery-powered version, Huang said. “Even though it could probably be reused, it’s meant to be disposable,” she said, demonstrating the tight fit between the steel tube that supports the wires and the motor.

Nadeem Dhanani, an assistant professor of surgery in the Division of Urology at the University of Texas Health Science Center at Houston, had previously worked on projects with students at Massachusetts Institute of Technology and approached Rice with a request for a better device. “I had what I thought was a good solution to this clinical challenge, but I also acknowledge the fact that I was looking at it from one direction,” he said. “Getting to incorporate the thoughts and experience and expertise of people with different backgrounds is a great opportunity.”

Dhanani, who is mentoring the students with Rice engineering lecturer Eric Richardson, described current techniques to remove clots at a patient’s bedside as antiquated. “We’re often forced to take patients to the operating room despite their poor health because we have no other alternative. If we’re able to save them the additional hazards of surgery and an anesthetic, we would be doing them a great service,” he said.

Team Evacuator focused first on safety. One advantage of their device is that the clot-busting wires are unlikely to contact the bladder’s inside wall. “We also found that switching the direction of the spin at intervals breaks up the clot a lot better that one continuous direction, so we’re building that function into the motorized version,” Hu said of the team’s tests on pig blood and gelatin.

The students are pleased with the simple, functional product of their capstone project, a requirement for most students at Rice’s George R. Brown School of Engineering. “When we’re done with this at the end of the semester, it will be a finished product,” Gallegos said.

“For us, the best outcome will be seeing this device go even further. Realistically, we can get right to the stage before animal testing, and that’s a major point,” Hu added.

“(The device is) cost-effective, easily accessible and relevant at the point of care and has a chance of actually being welcomed and adopted by the intended audience — the operators — because it’s intuitive for them and utilizes their skill sets,” Dhanani said. “We came up with a good solution.”

Related Articles Read More >

A portrait of Dr. Philip Adamson
Expect more heart and lung failure years after COVID, Abbott’s heart failure CMO says
iRhythm stays silent on federal grand jury subpoenas
iRhythm stock soars on Street-beating Q1
A Medtronic HVAD pump opened up to show the inner workings
Medtronic investigates HVAD pump welds after patient deaths

DeviceTalks Weekly.

May 20, 2022
DeviceTalks Boston Post-Game – Editors’ Top Moments, Insulet’s Eric Benjamin on future of Omnipod 5
See More >

MDO Digital Edition

Digital Edition

Subscribe to Medical Design & Outsourcing. Bookmark, share and interact with the leading medical design engineering magazine today.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
DeviceTalks

DeviceTalks is a conversation among medical technology leaders. It's events, podcasts, webinars and one-on-one exchanges of ideas & insights.

DeviceTalks

New MedTech Resource

Medical Tubing

Enewsletter Subscriptions

Enewsletter Subscriptions

MassDevice

Mass Device

The Medical Device Business Journal. MassDevice is the leading medical device news business journal telling the stories of the devices that save lives.

Visit Website
MDO ad
Medical Design and Outsourcing
  • MassDevice
  • DeviceTalks
  • MedTech 100 Index
  • Medical Tubing + Extrusion
  • Drug Delivery Business News
  • Drug Discovery & Development
  • Pharmaceutical Processing World
  • R&D World
  • About Us/Contact
  • Advertise With Us
  • Subscribe to Print Magazine
  • Subscribe to E-newsletter
  • Attend our Monthly Webinars
  • Listen to our Weekly Podcasts
  • Join our DeviceTalks Tuesdays Discussion

Copyright © 2022 WTWH Media, LLC. All Rights Reserved. Site Map | Privacy Policy | RSS

Search Medical Design & Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech