A new study indicates that a much higher proportion of patients with advanced chronic kidney disease (CKD)—even those ≥85 years of age—receive renal replacement therapy (RRT) such as maintenance dialysis or kidney transplantation in the United States than in other developed countries.

The findings, which appear in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN), suggest that decisions about RRT in the United States may not be strongly guided by the individual considerations of patients, and instead reflect wider practices favoring interventions to lengthen life.

The U.S. Medicare Program spends more than $30 billion annually to provide RRT to patients of any age who have advanced CKD. It’s unknown, however, how often U.S. patients with advanced CKD do not receive RRT. In other developed countries, receipt of RRT is highly age-dependent and is the exception rather than the rule at older ages. 

Susan Wong, M.D. (University of Washington) and her colleagues conducted a retrospective study to determine how often patients with advanced CKD do not receive RRT, the characteristics of these patients, and the clinical context in which decisions about RRT occur. 

The team identified a national cohort of 28,568 patients with very advanced CKD who were receiving care within the Department of Veteran Affairs (VA) between 2000 and 2009. Using a combination of linked administrative data from the VA, Medicare, and the United States Renal Data System (the U.S. national registry of RRT), the investigators identified patients who received RRT through October 1, 2010. For the remaining cohort members, the researchers performed an in-depth review of the VA-wide electronic medical record for a random 25 percent sample to understand the clinical course and treatment status of their CKD.

Based on administrative data, the researchers found that 67.1 percent of cohort members received RRT. Based on the results of chart review, the team estimates that an additional 7.5 percent of cohort members had in fact received at least one dialysis treatment not captured in administrative data, 10.9 percent were discussing and/or preparing for dialysis but had not yet started dialysis at the end of follow-up, and a decision had been made not to pursue dialysis in 14.5 percent of patients. 

Thus, at most recent follow-up, the overwhelming majority (85.5 percent) of patients had either received, or were preparing to receive, RRT. Even among members of the oldest age group (≥85 years) with the highest burden of comorbidity, most (51.2 percent) received or were preparing to receive RRT at the last follow-up point.

“Our findings signal more liberal use of dialysis in our study cohort as compared with other developed countries, with differences being especially striking for older age groups,” said Dr. Wong. In Canada, investigators estimated that 51.4 percent of patients with kidney failure, and only 6.8 percent of those ≥85 years, are treated with RRT. In New Zealand and Australia, an estimated 51.2 percent of patients, and <5.0 percent of elderly patients, are treated with RRT.

“Life expectancy after initiation of maintenance dialysis in very old patients is severely limited, and older patients experience high rates of hospitalization and transition to assisted nursing facilities after initiation of treatment,” Dr. Wong explained. Recent observational studies conducted in European countries have also raised concerns that dialysis may not meaningfully lengthen survival and is associated with poorer quality-of-life as compared with more palliative approaches, such as hospice, for older patients with significant comorbidity.

“Our findings underscore the importance of shared decision-making for dialysis to ensure that treatment decisions uphold the priorities and preferences of individual patients and are grounded in realistic expectations about prognosis and the expected benefits and harms of this treatment,” said Dr. Wong.

In an accompanying editorial, Jennifer Scherer, M.D. (NYU School of Medicine) and Alvin Moss, M.D. (West Virginia University) noted that changes are needed in the practice of kidney care, or nephrology. “Despite the integration of palliative care into the care of patients with cancer and other chronic diseases, a national policy shift towards patient-centered care, and recognition by nephrology fellows over a decade ago that more palliative care education is needed in their training, Wong et al. have shown that nephrology practice in the United States has not kept pace,” they wrote.

“The leaders in the nephrology interdisciplinary community including nephrologists, nurses, social workers, dietitians, and technicians, in collaboration with palliative care clinicians, need to make the implementation of a comprehensive model of renal supportive care delivery a priority for the growing population of older patients with advanced CKD,” they added.

Study co-authors include Paul L. Hebert, Ph.D., Ryan J. Laundry, BA, Kenric W. Hammond, M.D., Chuan-Fen Liu, Ph.D., Nilka R. Burrows, MPH, and Ann M. O’Hare, M.D., M.A.

Disclosures: This work was supported by VA Health Services Research and Development grants (IIR 09-094, PI Hebert; and IIR 12-126, PI O’Hare) and an Interagency Agreement between the VA Puget Sound and the Centers for Disease Control and Prevention (IAA 15FED1505101-0001; PI O’Hare). S.P.W. is supported by the Clinical Scientist in Nephrology Fellowship from the American Kidney Fund. A.M.O. receives research funding from the National Institutes of Health, Centers for Disease Control and the VA Health Services Research and Development Service. She also receives an honorarium from the American Society of Nephrology and royalties from UpToDate. C.F.L. and P.L.H. receive research funding from the VA Health Services Research and Development Service. The authors disclose no conflict of interests.

The article, entitled “Decisions about Renal Replacement Therapy in Patients with Advanced Kidney Disease in the US Department of Veterans Affairs, 2000-2011,” appeared online at http://cjasn.asnjournals.org/ on September 22, 2016, doi: 10.2215/CJN.03760416. 

The editorial, entitled “Practice Change Is Needed for Dialysis Decision-making with Older Patients with Advanced Kidney Disease, also appeared online at http://cjasn.asnjournals.org/ on September 22, 2016.

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(Source: Newswise)