Medical Design and Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • Subscribe to Print Magazine
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech

Study Suggests Need for Renal Protective Care in Pediatric Lung Transplant Patients

May 18, 2015 By American Thoracic Society

The study, believed to be the first to look at CKD in children who have received lung transplants, also found that those children with high levels of tacrolimus circulating in the blood and those who experience at least one episode of acute kidney injury during their recovery also appear to be at greater risk for CKD.Caucasian and Hispanic children who undergo lung transplantation appear to be at greater risk for developing chronic kidney disease, or CKD, according to a small retrospective study conducted at Texas Children’s Hospital. The study, believed to be the first to look at CKD in children who have received lung transplants, also found that those children with high levels of tacrolimus, a powerful immunosuppressant given to fight organ rejection, circulating in the blood and those who experience at least one episode of acute kidney injury during their recovery also appear to be at greater risk for CKD.

“These results show tendencies that need to be explored further,” said lead investigator Maria Gazzaneo, MD, who will present her research at ATS 2015, May 15-20, in Denver. “Still, we believe these results suggest pediatric lung transplantation patients can benefit from renal protective strategies.”

At Texas Children’s Hospital, where Dr. Gazzaneo is assistant professor of pediatric critical care and lung transplantation, the health care team now measures tacrolimus levels and kidney function twice a day. When possible, they try to reduce tacrolimus dosage, particularly in the first seven days post-surgery. The transplant team also involves nephrologists earlier in the care of any child who appears to be a risk for CKD.

Dr. Gazzaneo examined the medical records of 38 children who received a lung transplant at her hospital between 2012 and 2014. Two were excluded because they died within two months of the surgery. Of the 36 others, 5, or 13.8%, developed CKD within one year of transplantation based on criteria established by an international clinical guideline, Kidney Disease: Improving Global Outcomes (KDIGO).

Three of the children with CKD were Caucasian and two were Hispanic. Tacrolimus levels were elevated (15 ng/ml or higher) during the first seven post-operative days in 80% of those who developed CKD. All patients who developed CKD had at least one episode of acute kidney injury, or AKI. Among the children who did not develop CKD, the incidence of AKI was 71 percent.

Dr. Gazzaneo noted that CKD almost always presents a life-long challenge that can lead to many other complications, including hypertension, anemia, growth retardation and bone disease. “The patients who developed CKD in our study were adolescents,” she said. “If we could spare them this complication, it would greatly enhance their quality of life for the rest of their lives.”

Related Articles Read More >

Minnetronix Medical's MindsEye expandable port is a cone-shaped device for deep brain access
Contract manufacturer Minnetronix Medical launches its first in-house product, MindsEye
A portrait of Jennifer Fried, the founder of Explorer Surgical
What’s next for Jennifer Fried after leaving Explorer Surgical?
Prix Galien USA 2022 nominees
The 24 best medical device innovations of 2022
Wire mesh that has captured a blood clot
How an Embotrap stent retriever thrombectomy treats ischemic strokes

DeviceTalks Weekly.

August 12, 2022
DTW – Medtronic’s Mauri brings years of patient care to top clinical, regulatory, scientific post
See More >

MDO Digital Edition

Digital Edition

Subscribe to Medical Design & Outsourcing. Bookmark, share and interact with the leading medical design engineering magazine today.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
DeviceTalks

DeviceTalks is a conversation among medical technology leaders. It's events, podcasts, webinars and one-on-one exchanges of ideas & insights.

DeviceTalks

New MedTech Resource

Medical Tubing

Enewsletter Subscriptions

Enewsletter Subscriptions

MassDevice

Mass Device

The Medical Device Business Journal. MassDevice is the leading medical device news business journal telling the stories of the devices that save lives.

Visit Website
MDO ad
Medical Design and Outsourcing
  • MassDevice
  • DeviceTalks
  • MedTech100 Index
  • Medical Tubing + Extrusion
  • Medical Design Sourcing
  • Drug Delivery Business News
  • Drug Discovery & Development
  • Pharmaceutical Processing World
  • R&D World
  • About Us/Contact
  • Advertise With Us
  • Subscribe to Print Magazine
  • Subscribe to E-newsletter
  • Attend our Monthly Webinars
  • Listen to our Weekly Podcasts
  • Join our DeviceTalks Tuesdays Discussion

Copyright © 2022 WTWH Media, LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media LLC. Site Map | Privacy Policy | RSS

Search Medical Design & Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • Subscribe to Print Magazine
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech