Our Weekly Checkup takes the temperature of the medical device industry’s three largest U.S. clusters: Massachusetts, California and Minnesota.

The MassDevice Indices are weighted according to market capitalization, based on the number of shares outstanding for each company and each Friday’s closing share price.

The Massachusetts index for the week ended June 4 closed at 5.75, down 1.6 percent compared with the prior week. Since Jan. 1, 2009, when we began tracking these companies, the index has risen 29.8 percent.

The Minnesota index for the week ended June 4 closed at 3.56, down 8.2 percent compared with the prior week. Since Jan. 1, 2009, when we began tracking these companies, the index has risen 20.6 percent.

The California index for the week ended June 4 closed at 8.74, up 0.8 percent compared with the prior week. Since Jan. 1, 2009, when we began tracking these companies, the index has risen 106.0 percent.

We also create a composite index of the three regional indices and compare it with four other indices (the S&P 500, the Dow Jones Industrial Average, the Dow’s IHI medical devices index and the NASDAQ exchange):

The Weekly Checkup also compares Monday morning’s opening share prices with their value when the markets close Friday afternoon to calculate the biggest gainers and losers.

Here are the 20 firms that posted the biggest share price gains and losses during the week ended June 4:

The 10 biggest gainers:

1. Biopure Corp.: 100.0% (open $0.02; close $0.04)
2. Ophthalmic Imaging Systems: 35.5% (open $0.76; close $1.03)
3. Trimedyne Inc.: 23.2% (open $0.28; close $0.34)
4. Hypertension Diagnostics Inc.: 12.5% (open $0.16; close $0.18)
5. Micrus Endovascular Corp.: 10.3% (open $17.12; close $18.88)
6. LeMaitre Vascular Inc.: 8.0% (open $5.37; close $5.80)
7. Cambridge Heart Inc.: 7.3% (open $0.26; close $0.28)
8. Uroplasty Inc.: 6.8% (open $5.00; close $5.34)
9. Vision-Sciences Inc.: 6.1% (open $0.98; close $1.04)
10. Edwards Lifesciences Corp.: 4.5% (open $50.22; close $52.46)

Sources: Google Finance and Yahoo! Finance.

And the 10 biggest losers:

1. Viking Systems Inc.: -14.3% (open $0.28; close $0.24)
2. Intraop Medical Corp.: -14.3% (open $0.14; close $0.12)
3. HepaLife Technologies: -12.5% (open $0.16; close $0.14)
4. Patient Safety Technologies Inc.: -9.4% (open $0.85; close $0.77)
5. Thermage Inc. (Solta Medical Inc.): -9.2% (open $2.61; close $2.37)
6. World Heart Inc.: -8.9% (open $2.48; close $2.26)
7. Enteromedics Inc.: -8.9% (open $0.35; close $0.32)
8. Iridex Corp.: -8.8% (open $4.00; close $3.65)
9. icad Inc.: -7.5% (open $1.60; close $1.48)
10. Dexcom Inc.: -7.3% (open $10.34; close $9.59)

Sources: Google Finance and Yahoo! Finance.

Disclaimer: MassDevice.com’s rankings do not reflect an opinion of companies’ health, prospects or viability. They are intended to provide a snapshot of publicly traded medical device companies and in no way constitute a recommendation to buy or sell any particular security, portfolio of securities, transaction or investment strategy.

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