Our Weekly Checkup takes the temperature of the
medical device industry’s three largest U.S. clusters:
Massachusetts, California and Minnesota.

The MassDevice Indices are weighted according to market
capitalization, based on the number of shares outstanding for each
company and each Friday’s closing share price.

The Massachusetts index for the week ended May 21 closed at 5.70,
up 40.2 percent compared with the prior week. Since Jan. 1, 2009,
when we began tracking these companies, the index has risen 28.7
percent.

The Minnesota index for the week ended May 21 closed at 3.66, down
3.8 percent compared with the prior week. Since Jan. 1, 2009, when
we began tracking these companies, the index has risen 24.0
percent.

The California index for the week ended May 21 closed at 9.29, down
2.9 percent compared with the prior week. Since Jan. 1, 2009, when
we began tracking these companies, the index has risen 119.0
percent.

We also create a composite index of the three regional indices
and compare it with four other indices (the S&P 500, the Dow
Jones Industrial Average, the Dow’s IHI medical devices index and
the NASDAQ exchange):

The Weekly Checkup also compares Monday
morning’s opening share prices with their value when the markets
close Friday afternoon to calculate the biggest gainers and
losers.

Here are the 20 firms that posted the biggest share price gains
and losses during the week ended May 21 :

The 10 biggest gainers:

1. Trimedyne Inc.: 12.9% (open $0.31; close
   $0.35)
2. Oculus Innovative Sciences Inc. (Micromed):
   11.7% (open $1.97; close $2.20)
3. Vascular Solutions Inc.: 4.1% (open $10.25;
   close $10.67)
4. LeMaitre Vascular Inc.: 3.7% (open $5.10;
   close $5.29)
5. Cardiogenesis Corp.: 2.7% (open $0.37; close
   $0.38)
6. ICU Medical Inc.: 2.3% (open $31.44; close
   $32.15)
7. Biomerica Inc.: 2.1% (open $0.48; close
   $0.49)
8. Charles River Laboratories International Inc.:
   1.2% (open $31.92; close $32.30)
9. HeartWare International Inc.: 1.0% (open
   $54.07; close $54.59)
10. Ophthalmic Imaging Systems: 0.9% (open $1.08;
    close $1.09)

Sources: Google Finance and Yahoo! Finance.

And the 10 biggest losers:

1. Biopure Corp.: -50.0% (open $0.02; close
   $0.01)
2. NMT Medical Inc.: -23.5% (open $3.66; close
   $2.80)
3. Enteromedics Inc.: -23.3% (open $0.43; close
   $0.33)
4. Cambridge Heart Inc.: -21.9% (open $0.32;
   close $0.25)
5. AdvanSource Biomaterials Corp.: -20.0% (open
   $0.40; close $0.32)
6. Cynosure Inc.: -19.6% (open $13.19; close
   $10.60)
7. Palomar Medical Technologies Inc.: -17.3%
   (open $12.66; close $10.47)
8. Patient Safety Technologies Inc.: -17.0% (open
   $0.88; close $0.73)
9. Cytori Therapeutics Inc.: -16.9% (open $5.20;
   close $4.32)
10. Intraop Medical Corp.: -16.7% (open $0.18;
    close $0.15)

Sources: Google Finance and Yahoo! Finance.

Disclaimer: MassDevice.com’s rankings do
not reflect an opinion of companies’ health, prospects or
viability. They are intended to provide a snapshot of publicly
traded medical device companies and in no way constitute a
recommendation to buy or sell any particular security, portfolio of
securities, transaction or investment strategy.

SOURCE