Medical Design and Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Supplies and Components Index
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • MedTech Resources
    • Medtech Events in 2025
    • The 2024 Medtech Big 100
    • Medical Device Handbook
    • MedTech 100 Index
    • Subscribe to Print Magazine
    • DeviceTalks
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Podcasts
    • Print Subscription
    • Webinars / Digital Events
    • Whitepapers
    • Voices
    • Video
  • 2025 Leadership
    • 2024 Winners
    • 2023 Winners
    • 2022 Winners
    • 2021 Winners
  • Women in Medtech
  • Advertise
  • Subscribe

Transcranial Direct Current Stimulation Can Boost Language Comprehension

April 8, 2016 By Perelman School of Medicine at the University of Pennsylvania

How the human brain processes the words we hear and constructs complex concepts is still somewhat of a mystery to the neuroscience community. Transcranial direct current stimulation (tDCS) can alter our language processing, allowing for faster comprehension of meaningful word combinations, according to new research from the department of Neurology the Perelman School of Medicine at the University of Pennsylvania. The work is published in the Journal of Neuroscience.

“Integrating conceptual knowledge is one of the neural functions fundamental to human intelligence,” said the study’s first author Amy Price, a neuroscience graduate student at Penn. “For example, when we read or listen to a sentence, we need to combine, or integrate, the meaning of the words to understand the full idea of the sentence. We perform this process effortlessly on a daily basis but it is quite a complex process and little is known about the brain regions that support this ability.”

Semantic memory is our stored knowledge about the world, such as the meaning of words and objects. “We sought to understand how and in what part of the brain semantic representations are integrated into more complex ideas” said senior author Roy Hamilton, MD, MS, an assistant professor in the departments of Neurology and Physical Medicine & Rehabilitation, and director of the Laboratory for Cognition and Neural Stimulation at Penn. Recent findings from functional MRI scans (fMRI) and magnetoencephalography (MEG) have suggested the angular gyrus, a region of the brain known to be involved in language, number processing and spatial cognition, memory retrieval and attention, as a potential hub for semantic memory integration, specifically the left angular gyrus.

Hamilton and team, which also included Jonathan Peelle PhD, an assistant professor in the Department of Otolaryngology at the Washington University School of Medicine, Michael Bonner, PhD, a postdoctoral fellow in the Department of Psychology at Penn, and Murray Grossman, MD, EdD, professor of Neurology and director of the Penn Frontotemporal Dementia Center, looked at the role of the left angular gyrus in semantic memory by applying high definition tDCS in healthy adults to modulate neural activity and determine its effect on semantic integration. This was done using three separate brain stimulation sessions in 18 healthy adults. Subjects donned the tDCS stimulation cap equipped with electrodes that stimulated the left angular gyrus or the right angular gyrus, as well as applied a fake form of stimulation known as sham stimulation as a control. After each stimulation session, subjects were presented with word pairs that could to be semantically integrated into coherent, or meaningful, combinations—such as “plaid jacket” and another set of word pairs that formed non-coherent, or non-meaningful combinations- such as “fast blueberry.”

This was followed by a letter task that served as a control for brain stimulation effects on vision and attention, in which subjects looked at non-pronounceable strings of letters – such as vsbsl vsbql – and were asked to indicate whether or not the letter strings matched.

Results showed that stimulation to the left angular gyrus resulted in a faster comprehension of meaningful relative to non-meaningful word pairs when compared with both sham and right angular gyrus stimulation. This same effect was not produced in the letter-string task, showing that these findings cannot be easily attributed to non-specific effects on attention, motor control or low-level visual processing.

“Our findings extend our knowledge about the angular gyrus as a center wherein the brain constructs higher-level meaning from individual words during semantic comprehension and plays an important role in the fluent composition of meaning in language,” Hamilton said. “They are also consistent with the broader claim that the angular gyrus is a cortical semantic hub.”

Related Articles Read More >

How this device broke through the blood-brain barrier
A photo of the miniature Auxilium Biotechnologies implants made on the International Space Station.
Implants 3D-printed in space could enable nerve regeneration
An illustration showing the Artedrone Sasha thrombectomy catheter approaching a blood clot.
This microrobot system is designed to float inside a stroke patient for autonomous thrombectomy
A photo of nitinol, a nickel-titanium alloy used for medical devices such as stents, heart valves, catheters and orthopedics.
What is nitinol and where is it used?
“mdo
EXPAND YOUR KNOWLEDGE AND STAY CONNECTED
Get the latest medical device business news, application and technology trends.

DeviceTalks Weekly

See More >

MDO Digital Edition

Digital Edition

Subscribe to Medical Design & Outsourcing. Bookmark, share and interact with the leading medical design engineering magazine today.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
DeviceTalks

DeviceTalks is a conversation among medical technology leaders. It's events, podcasts, webinars and one-on-one exchanges of ideas & insights.

DeviceTalks

New MedTech Resource

Medical Tubing

MassDevice

Mass Device

The Medical Device Business Journal. MassDevice is the leading medical device news business journal telling the stories of the devices that save lives.

Visit Website
MDO ad
Medical Design and Outsourcing
  • MassDevice
  • DeviceTalks
  • MedTech100 Index
  • Medical Tubing + Extrusion
  • Medical Design Sourcing
  • Drug Delivery Business News
  • Drug Discovery & Development
  • Pharmaceutical Processing World
  • R&D World
  • About Us/Contact
  • Advertise With Us
  • Subscribe to Print Magazine
  • Subscribe to our E-Newsletter
  • Listen to our Weekly Podcasts
  • Join our DeviceTalks Tuesdays Discussion

Copyright © 2025 WTWH Media, LLC. All Rights Reserved. The material on this site may not be reproduced, distributed, transmitted, cached or otherwise used, except with the prior written permission of WTWH Media LLC. Site Map | Privacy Policy | RSS

Search Medical Design & Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Supplies and Components Index
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • MedTech Resources
    • Medtech Events in 2025
    • The 2024 Medtech Big 100
    • Medical Device Handbook
    • MedTech 100 Index
    • Subscribe to Print Magazine
    • DeviceTalks
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Podcasts
    • Print Subscription
    • Webinars / Digital Events
    • Whitepapers
    • Voices
    • Video
  • 2025 Leadership
    • 2024 Winners
    • 2023 Winners
    • 2022 Winners
    • 2021 Winners
  • Women in Medtech
  • Advertise
  • Subscribe