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Hybrid Organic-Inorganic Materials Can Self-Assemble into Tiny Doughnut-Like Structures

January 17, 2017 By Phys.org

Engineered nanometer- and micrometer-scale structures have a vast array of uses in electronics, sensors, and biomedical applications. Because these are difficult to fabricate, KAUST researchers are trying a bottom-up philosophy, which harnesses the natural forces between atoms and molecules such that microstructures form themselves.

This approach, a departure from the usual top-down approach, involves the etching away of material to leave the desired sculpted structure behind; however, because this approach can be tricky, expensive and time consuming, KAUST researchers became motivated to find a new approach.

(Credit: KAUST/Xavier Pita)

Associate Professor of Chemical Science Niveen Khashab and her team and colleagues from the Imaging and Characterization Core Lab and the Max-Planck-Institute of Colloids and Interfaces in Germany demonstrated this bottom-up approach in the self-assembly of microscale toroids (doughnut-shaped forms), made of both inorganic and organic materials.

A number of forces can bring atoms and molecules together including surface tension, electrostatic attraction, and repulsion, and a weak fundamental force known as van der Waals interactions.

The toroids created by Khashab’s team were formed via metal coordination.

A metallic sodium chloride atom, an amphiphilic (both hydrophilic and lipophilic) molecule called saponin and a polymer known as chitosan were combined and formed weak chemical bonds.

“This is a result of what is known as coordination-driven self-assembly,” explains Khashab. “The metal ions interact with different chemical motifs leading to the formation of novel frameworks and morphologies.”

Within just a few minutes, coordination bonding between the iron atoms and the oxygen and the hydrogen in the molecules initially drives the self-assembly of star-like nanostructures. Repulsive electrostatic and hydrophobic interactions then lead to the formation of toroids.

The toroids were approximately 3.9 to 4.8 micrometers in diameter and held their shape even a month after fabrication. Disassembly of the microstructures required five hours of mechanically stirring the solution.

There are numerous naturally occurring biological structures that take a toroid shape; for example, proteins and DNA of some types of viruses and bacteria self-assemble in this way. Many of these are known to play an important role in the formation of pores in biomembranes.

This research could help to build a better understanding of how these complex biostructures are created and provide a way of mimicking them at the molecular level.

“Next, we hope to prepare a new generation of these hybrid structures with a temperature-responsive gap size,” says Khashab. “These toroid structures could be used as pockets for active catalysis and separation.”

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