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DiFusion Inc. Announces Breakthrough SMART Biomaterial Platform

April 25, 2017 By DiFusion Inc.

(Credit: PRNewsfoto/DiFusion Inc.)

DiFusion announced the completion of a series of in vitro tests and in vivo studies, carried out in part at Clemson University and the Simmons Institute at Alleghany Medical, which validate the efficacy of its new SMART polymer platform with multiple breakthrough applications. DiFusion holds six US Patents and over 80 international patents which cover new load bearing implantable medical polymers with various applications ranging from antimicrobial, increased angiogenesis, tissue regeneration, collagen formation, and increased osteoconduction.

ZFUZE is a new load bearing medical polymer which has recently concluded in vivo animal studies to be presented at The Annual Medical PEEK Symposium on April 28 in Washington DC.

“We are very pleased to have reached this milestone for our second medical polymer, ZFUZE which has demonstrated the ability to have bone be attracted strongly enough to its surface that it grows across a critical bone defect model in a skeletally mature rabbit,” says DiFusion Founder and CEO Derrick Johns.  This is a remarkable achievement for an implantable polymer as it is difficult for skeletally mature animals to grow new bone let alone for it to jump a void.

“I am extremely excited by the recent ZFUZE study results in a critical defect animal model. The base technology underlying these polymers will clearly evolve into the realm of regenerative medicine as the ongoing R&D expands its clinical applications. I think the technology could eventually rival that of drug eluting scaffolds given our early findings and results.” – Paul Kraemer, MD Indianapolis Spine Institute. https://vimeo.com/214500384

ZFUZE follows CleanFuze a load bearing antimicrobial polymer which has been approved in the European Union via ISO 13485 CE Mark. In a separate in vivo study at Clemson University, CleanFuze demonstrated that it resists biofilm formation and did not allow any microbial colonization of the implant surface. Third party in vitro antimicrobial testing revealed a 99.9999 percent reduction in MRSA and S.aureus colonies, compared to a competitive antimicrobial material-silicon nitride and titanium spinal implants; which showed no antimicrobial efficacy relative to CleanFuze.

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