Medical Design and Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech

Researchers Create First Soluble 2D Supramolecular Organic Frameworks

December 17, 2013 By Lynn Yarris, Lawrence Berkeley National Laboratory

Supramolecular chemistry, aka chemistry beyond the molecule, in which molecules and molecular complexes are held together by non-covalent bonds, is just beginning to come into its own with the emergence of nanotechnology. Metal-organic frameworks (MOFs) are commanding much of the attention because of their appetite for greenhouse gases, but a new player has joined the field—supramolecular organic frameworks (SOFs). Researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) have unveiled the first two-dimensional SOFs that self-assemble in solution, an important breakthrough that holds implications for sensing and separation technologies, energy sciences, and, perhaps most importantly, biomimetics.

“We’ve demonstrated the first soluble single-layer 2D honeycomb SOF that combines the ordering and porous features of MOFs with the solubility of supramolecular polymers,” says Yi Liu, a chemist with Berkeley Lab’s Materials Sciences Division. “The results prove that we can exercise precise control of dimensionality within structures through a solution-based supramolecular approach, which paves the way for the assembly of more advanced architectures that can be processed in solution.”

Photos of the Day: SOFs for Biomimetics

Liu, who oversees the supramolecular electronics research group at Berkeley Lab’s Molecular Foundry, a DOE national nanoscience user facility, is one of three corresponding authors of a paper describing this research in the Journal of the American Chemical Society (JACS). The paper is titled “Toward a Single-Layer Two-Dimensional Honeycomb Supramolecular Organic Framework in Water.” The other corresponding authors are Xin Zhao and Zhan-Ting Li, of China’s Shanghai Institute of Organic Chemistry and Fudan University.

Traditional molecular chemistry involves the strong covalent bonds formed by the sharing or exchange of electrons between the atoms that make up a molecular system. Supramolecular chemistry involves systems that are held together by a multitude of weaker, non-covalent connections, such as hydrogen bonds and electrostatic and Van der Waals forces. Nature uses supramolecular chemistry to form the double-helix of DNA or to fold proteins. For nanotechnology, single-layers of 2D structurally ordered materials—along the lines of graphene—could fill a great many needs but the key is to process them in solution.

“Solution-based processing allows for mass production and reduced manufacturing costs, and is an important step for transferring materials to a dry state without losing their structural integrity,” Yi says. “Solution-based processing also allows for bio-related applications such as biomimetic sensing, where the framework structure is advantageous for the capturing of guest molecules and the amplification of chemical signals.”

However, the self-assembly of well-defined 2D supramolecular systems polymers in solution has been a challenge because such polymers tend to precipitate out of solution, making them difficult to manipulate and characterize. To meet this challenge, Yi and his collaborators used a combination of self-assembling tripods and marocycle rings to form a porous framework with honeycomb periodicity, similar to that of a MOF, but which remains rigid in solution. Equipping the tripods with bulky hydrophilic groups that resist stacking preserved the solubility and single-layer 2D architecture of the framework.

“That our framework is held together by reversible, non-covalent supramolecular interactions ensures good solubility in water,” Li says. “The precise dimensional control of our solution-based processing facilitates the structural and chemical customization of our frameworks.”

The tripods of these SOFs were made from aromatic bipyridine molecules whose trio of struts or arms were interlocked with the struts of their neighboring molecules through the macrocycles, which were made from cucurbituril molecules. The molecules used in this study were proof-of-principle starters. Other molecules for the struts could be employed in the future for the design of similar or more complex architectures. The 2D single-layer structures of these first SOFs were characterized at Berkeley Lab’s Advanced Light Source, another DOE national user facility, using small angle X-ray scattering (SAXS) technologies at beamlines 12.3.1 and 7.3.3.

Yi and his collaborators at the Molecular Foundry and in Shanghai are now working to create soluble SOFs in 3D. In addition to the corresponding authors, other authors of the JACS paper were Kang-Da Zhang, Jia Tian, David Hanifi, Yuebiao Zhang, Andrew Chi-Hau Sue, Tian-You Zhou and Lei Zhang.

This research was supported by the DOE Office of Science.

Related Articles Read More >

Dexcom One
How Dexcom’s portfolio goes beyond highly-anticipated next-gen G7
A portrait of Stryker executive Siddarth Satish
How Stryker includes users for product design in the digital age
A Medtronic HVAD pump opened up to show the inner workings
Medtronic investigates HVAD pump welds after patient deaths
Galien Foundation 2022 nominees
18 of the world’s most innovative medical technologies

DeviceTalks Weekly.

May 13, 2022
Our Pre-Post-DeviceTalks Boston episode, also MedtronicTalks replay with Gastro CMO Austin Chiang
See More >

MDO Digital Edition

Digital Edition

Subscribe to Medical Design & Outsourcing. Bookmark, share and interact with the leading medical design engineering magazine today.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
DeviceTalks

DeviceTalks is a conversation among medical technology leaders. It's events, podcasts, webinars and one-on-one exchanges of ideas & insights.

DeviceTalks

New MedTech Resource

Medical Tubing

Enewsletter Subscriptions

Enewsletter Subscriptions

MassDevice

Mass Device

The Medical Device Business Journal. MassDevice is the leading medical device news business journal telling the stories of the devices that save lives.

Visit Website
MDO ad
Medical Design and Outsourcing
  • MassDevice
  • DeviceTalks
  • MedTech 100 Index
  • Medical Tubing + Extrusion
  • Drug Delivery Business News
  • Drug Discovery & Development
  • Pharmaceutical Processing World
  • R&D World
  • About Us/Contact
  • Advertise With Us
  • Subscribe to Print Magazine
  • Subscribe to E-newsletter
  • Attend our Monthly Webinars
  • Listen to our Weekly Podcasts
  • Join our DeviceTalks Tuesdays Discussion

Copyright © 2022 WTWH Media, LLC. All Rights Reserved. Site Map | Privacy Policy | RSS

Search Medical Design & Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech