Medical Design and Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech

Microgel Powder Fights Infection And Helps Wounds Heal

November 28, 2018 By Michigan Technological University

While making smart glue, a team of engineers discovered a handy byproduct: hydrogen peroxide. In microgel form, it reduces bacteria and virus ability to infect by at least 99 percent.

Hao Meng’s doctoral project focused on biocompatibility testing and pulling a sticky amino acid out of mussels. Glue-like catechol shows promise for smart adhesives — a small jolt of electricity can turn the stickiness on and off — but that’s not its only potential use.

“In the process, Meng discovered the chemical reaction generated hydrogen peroxide as a byproduct of oxidation,” says Bruce Lee, associate professor of biomedical engineering and Meng’s PhD advisor at Michigan Technological University. “She started thinking, what if we could use the hydrogen peroxide?”

The answer is yes, and the technology that makes this portable, healing disinfectant possible is the subject of a new paper published in Acta Biomaterialia. The work brought together an interdisciplinary team of engineers to explore not only the tech development but also the material’s physical and biological properties. The coauthors include Caryn Heldt, James and Lorna Mack Chair in Bioengineering, and Megan Frost, interim chair of the Department of Kinesiology and Integrative Physiology as well as an associate professor of biomedical engineering and an affiliated associate professor of materials science and engineering.

Microgel powder turns into tiny bubbles of jello when mixed with a neutral pH solution and generates enough hydrogen peroxide to kick bacterial and viral infections for four days. (Image credit: Sarah Bird/Michigan Tech)

After Meng first observed that her reactions created hydrogen peroxide, she started considering the best form to put the byproduct in. She wanted lots of surface area to power the chemical reaction and she wanted a way to reuse the material. So, the team made a microgel.

“The gel is just like jello,” Lee says. “It’s a polymer network with a lot of water in it. And just like jello, we start with a liquid and solidify it into a shape.”

Microgels are like tiny bubbles of jello. To the naked eye, the dry form is a nondescript powder. Suspend it in a solution with neutral or a slightly alkaline pH, such as distilled water or a saline solution like contact lens cleaner, and the hydrogen peroxide cycle gets rolling. Left to its own devices, the micron-sized microgels generated between one to five millimolars over four days. Once the microgel powder is dried again, the material basically resets, sits safely contained in a small bag, and can be reused. It’s like an on-demand bottle of disinfectant — without the bulky bottle and hazardous storage issues.

The inspiration for that iconic brown bottle in the medicine cabinet didn’t start in a lab; the body naturally produces hydrogen peroxide to help heal cuts and the substance has been widely used medicinally to kill off bacteria and even viruses. Because the microgel powder continues to create and release hydrogen peroxide, its potency remains high, especially compared to the old-school cotton ball technique.

The team studied the microgel’s effects on two common bacterial strains and two structurally different viruses. That includes the thin-walled and gram-positive Staphylococcus epidermidis, as well as the more impenetrable and gram-negative Escherichia coli (E. coli). They also looked at the extremely resistant non-enveloped porcine parovirus (PPV) and easier to inactivate enveloped bovine viral diarrhea virus (BVDV). Because of the hard protein casing around PPV, which makes it and other non-enveloped viruses more resistant to biocides, the team was pleasantly surprised to see that the microgel still reduced the virus’ ability to infect cells by 99.9 percent. (In technical terms, that’s a three log reduction value of infectivity.) With BVDV, they observed a 99.999 percent reduction in infectivity.

Microgel Powder: Sticky catechol makes hydrogen peroxide; Safe and Dry: Storing liquid hydrogen peroxide can be dangerous, inert powder is more portable; Neutral pH: Adding a slightly buffered solution generates hydrogen peroxide; Mussel-derived: Amino acid used to make innovative adhesives; Clean and Heal: Disinfectant that boosts wound healing. (Image credit: Nicole Kelly/Michigan Tech)

The possibilities are almost endless. Wherever a small bag can go, so could this technology. Whether it’s backcountry travel, space stations, remote clinics or war zones, a little bit of healing to prevent infection can go a long way. While Lee and his team say the tech is not quite ready for Amazon Prime, they are hopeful that the work shows promise for a variety of applications, perhaps even with antibiotic resistance.

“We haven’t tested any antibiotic-resistant bacterial strains yet, but the more we can get away from using antibiotics in the first place, the better,” Lee says. “There’s still a lot of work to be done. We want to demonstrate under what conditions it promotes healing and how a cell responds to it. Hydrogen peroxide at high concentrations can also kill cells, so we need to have a balance that changes for different cell types.”

Related Articles Read More >

Lazurite ArthroFree wireless surgical camera system Minnetronix Medical
How Minnetronix Medical helped Lazurite with its wireless surgical camera
Medtronic Hugo robot-assisted surgery system
The road to a robot: Medtronic’s development process for its Hugo RAS system
A portrait of Stryker executive Siddarth Satish
How Stryker includes users for product design in the digital age
A portrait of Stryker executive Tracy Robertson
Stryker leaders talk medtech trends at DeviceTalks Boston: ‘If you’re slow, you’re going to lose’

DeviceTalks Weekly.

May 20, 2022
DeviceTalks Boston Post-Game – Editors’ Top Moments, Insulet’s Eric Benjamin on future of Omnipod 5
See More >

MDO Digital Edition

Digital Edition

Subscribe to Medical Design & Outsourcing. Bookmark, share and interact with the leading medical design engineering magazine today.

MEDTECH 100 INDEX

Medtech 100 logo
Market Summary > Current Price
The MedTech 100 is a financial index calculated using the BIG100 companies covered in Medical Design and Outsourcing.
DeviceTalks

DeviceTalks is a conversation among medical technology leaders. It's events, podcasts, webinars and one-on-one exchanges of ideas & insights.

DeviceTalks

New MedTech Resource

Medical Tubing

Enewsletter Subscriptions

Enewsletter Subscriptions

MassDevice

Mass Device

The Medical Device Business Journal. MassDevice is the leading medical device news business journal telling the stories of the devices that save lives.

Visit Website
MDO ad
Medical Design and Outsourcing
  • MassDevice
  • DeviceTalks
  • MedTech 100 Index
  • Medical Tubing + Extrusion
  • Drug Delivery Business News
  • Drug Discovery & Development
  • Pharmaceutical Processing World
  • R&D World
  • About Us/Contact
  • Advertise With Us
  • Subscribe to Print Magazine
  • Subscribe to E-newsletter
  • Attend our Monthly Webinars
  • Listen to our Weekly Podcasts
  • Join our DeviceTalks Tuesdays Discussion

Copyright © 2022 WTWH Media, LLC. All Rights Reserved. Site Map | Privacy Policy | RSS

Search Medical Design & Outsourcing

  • Home
  • Medical Device Business
    • Mergers & Acquisitions
    • Financial
    • Regulatory
  • Applications
    • Cardiovascular
    • Devices
    • Imaging
    • Implantables
    • Medical Equipment
    • Orthopedic
    • Surgical
  • Technologies
    • Contract Manufacturing
    • Components
    • Electronics
    • Extrusions
    • Materials
    • Motion Control
    • Prototyping
    • Pumps
    • Tubing
  • Med Tech Resources
    • DeviceTalks Tuesdays
    • Digital Editions
    • eBooks
    • Manufacturer Search
    • Medical Device Handbook
    • MedTech 100 Index
    • Podcasts
    • Print Subscription
    • The Big 100
    • Webinars / Digital Events
    • Whitepapers
    • Video
  • 2022 Leadership in MedTech
    • 2022 Leadership Voting!
    • 2021 Winners
    • 2020 Winners
  • Women in Medtech